NFL Week 2 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 2 schedule opens with the Detroit Lions visiting the Buffalo Bills on Thursday night and runs through a full slate of 16 games before the New York Giants visit the Los Angeles Rams on Monday night.

Sunday brings 14 games, including Packers-Jets, Commanders-Cowboys, Dolphins-49ers, and Colts-Chiefs. Several games have tight early spreads, while San Francisco, Seattle, the Chargers, and the Rams stand out as some of the week's biggest favorites.

Below is the complete NFL schedule for Week 2, followed by an early look at NFL Week 2 odds and predictions. Betting lines are a snapshot and can move significantly before kickoff.

NFL Week 2 Schedule

Here is the Week 2 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• Detroit Lions at Buffalo Bills — Thursday, Sept. 17, 8:15 p.m.
• Cincinnati Bengals at Houston Texans — Sunday, Sept. 20, 1:00 p.m.
• Cleveland Browns at Tampa Bay Buccaneers — Sunday, Sept. 20, 1:00 p.m.
• Pittsburgh Steelers at New England Patriots — Sunday, Sept. 20, 1:00 p.m.
• Green Bay Packers at New York Jets — Sunday, Sept. 20, 1:00 p.m.
• Carolina Panthers at Atlanta Falcons — Sunday, Sept. 20, 1:00 p.m.
• Philadelphia Eagles at Tennessee Titans — Sunday, Sept. 20, 1:00 p.m.
• New Orleans Saints at Baltimore Ravens — Sunday, Sept. 20, 1:00 p.m.
• Minnesota Vikings at Chicago Bears — Sunday, Sept. 20, 1:00 p.m.
• Jacksonville Jaguars at Denver Broncos — Sunday, Sept. 20, 4:05 p.m.
• Las Vegas Raiders at Los Angeles Chargers — Sunday, Sept. 20, 4:05 p.m.
• Washington Commanders at Dallas Cowboys — Sunday, Sept. 20, 4:25 p.m.
• Seattle Seahawks at Arizona Cardinals — Sunday, Sept. 20, 4:25 p.m.
• Miami Dolphins at San Francisco 49ers — Sunday, Sept. 20, 4:25 p.m.
• Indianapolis Colts at Kansas City Chiefs — Sunday, Sept. 20, 8:20 p.m.
• New York Giants at Los Angeles Rams — Monday, Sept. 21, 8:15 p.m.

The Week 2 NFL schedule is concentrated on Sunday, with eight games in the 1 p.m. window followed by four late-afternoon matchups and Colts-Chiefs on Sunday night. Lions-Bills and Giants-Rams provide the week's standalone Thursday and Monday games.

NFL Week 2 Odds

The early NFL Week 2 odds establish several clear favorites, but there are also a number of games with spreads around a field goal or less. The lines below are based on the supplied odds board and were reviewed Aug. 17, 2026. Because sportsbooks can move their numbers independently, these should be treated as an early betting-market snapshot rather than guaranteed closing lines.

Buffalo is around a three-point favorite against Detroit, while Houston is laying roughly 2.5 points against Cincinnati. Atlanta is also a narrow favorite against Carolina at around -1.5.

Some of the largest Week 2 NFL odds are attached to San Francisco, Seattle, the Chargers, and the Rams. The 49ers are roughly 10.5-point favorites over Miami, Seattle is around -9.5 against Arizona, and both the Chargers and Rams are favored by approximately 8.5 points.

Several games sit in a much tighter range. Bengals-Texans is around a 2.5-point spread, Panthers-Falcons is close to 1.5 points, and Jaguars-Broncos has Denver favored by roughly 2.5. Lions-Bills, Vikings-Bears, and Commanders-Cowboys are also priced around a field goal.

Totals vary considerably. Lions-Bills carries one of the highest early totals at roughly 52.5 points, while Browns-Buccaneers is sitting around 39.5.

With weeks remaining before kickoff, NFL odds for Week 2 can change because of injuries, roster developments, Week 1 results, and betting action. Check current numbers in the Hall of Fame Bets sports betting app before placing a wager.

NFL Week 2 Predictions

Early NFL Week 2 predictions should be treated differently from the schedule and betting lines: these are analytical leans, not factual outcomes or guarantees.

Lions at Bills: Buffalo gets the early lean. The Bills are favored by around a field goal at home, while the 52.5-point total makes this one of the higher-scoring games according to the early market.

Bengals at Texans: Houston gets a slight nod. A spread of roughly 2.5 points makes this one of the closer matchups on the Week 2 schedule.

Browns at Buccaneers: Tampa Bay is the early pick. The Buccaneers are favored by around 5.5 points at home, while the comparatively low total suggests a more modest scoring environment.

Steelers at Patriots: New England gets the prediction. The Patriots are favored by around 4.5 points at home, giving them a meaningful but not overwhelming early advantage.

Packers at Jets: Green Bay gets the nod. The Packers are laying roughly 5.5 points despite playing on the road, reflecting relatively strong early market support.

Panthers at Falcons: Atlanta gets a narrow lean. With the Falcons favored by only around 1.5 points, the early market sees little separation between the teams.

Eagles at Titans: Philadelphia is the pick. The Eagles are favored by around 4.5 points on the road, putting them in a stronger market position than several other visiting teams.

Saints at Ravens: Baltimore gets the early prediction. The Ravens are favored by roughly 7.5 points at home, making them one of the larger favorites in Sunday's early window.

Vikings at Bears: Chicago gets a slight edge. The Bears are favored by around three points at home, but the modest spread leaves Minnesota firmly in contention.

Jaguars at Broncos: Denver is the early pick. The Broncos are laying roughly 2.5 points at home in another matchup the market expects to remain competitive.

Raiders at Chargers: Los Angeles gets the prediction. The Chargers are favored by approximately 8.5 points, placing them among Week 2's biggest favorites.

Commanders at Cowboys: Dallas gets the lean at home. The Cowboys are favored by around three points, while the total above 50 points suggests the early market expects one of the week's more offense-friendly games.

Seahawks at Cardinals: Seattle is the pick. The Seahawks are favored by roughly 9.5 points on the road, giving them one of the strongest early positions on the Week 2 board.

Dolphins at 49ers: San Francisco gets the early prediction. At approximately -10.5, the 49ers are the largest favorite on the supplied Week 2 odds board.

Colts at Chiefs: Kansas City gets the lean in the Sunday night matchup. The Chiefs are favored by roughly 6.5 points at home, giving them a substantial early market advantage.

Giants at Rams: Los Angeles gets the Monday night prediction. The Rams are around 8.5-point favorites, putting them alongside San Francisco, Seattle, and the Chargers among the strongest favorites of Week 2.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 2?

Based on the supplied early NFL Week 2 odds, the 49ers are the biggest favorite, laying roughly 10.5 points against the Dolphins. Seattle is around a 9.5-point favorite over Arizona, while the Chargers and Rams are each favored by approximately 8.5 points.

Baltimore is also favored by more than a touchdown against New Orleans. At the opposite end of the spectrum, Panthers-Falcons, Bengals-Texans, and Jaguars-Broncos are among the closest games on the board.

Being favored does not mean a team is predicted to win with certainty. Point spreads reflect the betting market and can change substantially between the opening numbers and kickoff.

What Are the Odds for NFL Week 2?

NFL Week 2 odds include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for the combined points scored by both teams.

For Week 2 of the 2026 season, the supplied odds show a wide range of expectations. San Francisco is favored by roughly 10.5 points against Miami, while Atlanta is only around a 1.5-point favorite against Carolina. Other competitive games include Cincinnati-Houston and Jacksonville-Denver, both of which carry spreads around 2.5 points.

Bettors should compare the latest market before making a decision because these early numbers can move as Week 2 approaches.

Who Is Predicted to Win Week 2 in the NFL?

Our early Week 2 NFL predictions lean toward Buffalo, Houston, Tampa Bay, New England, Green Bay, Atlanta, Philadelphia, Baltimore, Chicago, Denver, the Chargers, Dallas, Seattle, San Francisco, Kansas City, and the Rams.

Those selections are preliminary. Week 1 results, injuries, roster changes, depth-chart decisions, and updated betting markets can alter the analysis before kickoff.

The Week 2 schedule offers a mix of close games and substantial favorites, with Lions-Bills opening the week and Giants-Rams closing it on Monday night. As kickoff approaches, updated NFL Week 2 odds and our sports betting app's matchup-specific analysis will provide a clearer picture of where the strongest predictions and betting opportunities may be.