Seahawks vs Cardinals NFL Picks and Predictions
The Seattle Seahawks are heavy road favorites against the Arizona Cardinals in a Week 2 NFC West matchup that comes with a major injury storyline at quarterback. We break down the odds, matchup numbers, injuries, and betting trends to land on the best Seahawks vs Cardinals pick. For the rest of the slate, check out our full Week 2 NFL Schedule with odds and predictions for every game.
You can explore all of this matchup data yourself with our sports betting research app, which we used to pull every stat in this breakdown.
Table of Contents
Seahawks vs Cardinals Odds and Betting Lines
Seattle is a significant road favorite, with the Seahawks listed at -6.5 (-153) and Arizona getting 6.5 points at +6.5 (-115). The moneyline has Seattle at -319 and Arizona at +268, while the total sits at 44.5, with both the over and under priced at -233.
A road favorite of this size reflects both Seattle's strong recent form and the uncertainty hanging over Arizona's roster heading into Sunday.
Seahawks vs Cardinals Matchup Breakdown
Seattle's offense grades out favorably across the board against an Arizona defense that has struggled. The Seahawks rank 6th in total rush and receiving yards (355.2) against a Cardinals defense that ranks 28th in yards allowed (358.5). Seattle ranks 10th in passing yards (224.9) facing an Arizona defense that ranks 24th against the pass (230.8 allowed), and 10th in rushing yards (124.7) against a Cardinals run defense that ranks 25th (128.9 allowed).
Touchdown production also favors Seattle: the Seahawks rank 12th in anytime touchdowns (2.6) against an Arizona defense that ranks 27th in touchdowns allowed (2.9), 12th in passing touchdowns (1.5) against a defense ranked 25th in passing touchdowns allowed (1.8), and 8th in rushing touchdowns (1.1) against a Cardinals defense ranked 25th in rushing touchdowns allowed (1.1).
The biggest story in this matchup is at quarterback. Seattle's Sam Darnold (hip) is doubtful, and backup Jalen Milroe is already out due to a coach's decision, creating real uncertainty about who starts under center for the Seahawks. Arizona's Jacoby Brissett carries a C Matchup grade, projected for 276.7 passing yards, 1.9 touchdowns, and 0.7 interceptions.
Seahawks vs Cardinals Injury Report
Beyond the quarterback uncertainty, Seattle is also missing running back Zach Charbonnet (surgery) and receiver Tory Horton (hamstring), both ruled out. Arizona's backfield is banged up as well, with both James Conner (foot) and Trey Benson (knee) already ruled out, along with tight end Tip Reiman (ankle). With Conner and Benson both out, Arizona's rushing attack could look very different than expected on Sunday.
Seahawks vs Cardinals Betting Trends
Seattle has covered the spread in 57% of its games, while Arizona has covered as an underdog in 59% of its games. Straight up, the Seahawks have won 86% of their games and the Cardinals have won just 18% of theirs.
The total has trended over in Arizona games (65% over) but closer to even in Seattle games (52% over), which points toward the over as the side with more recent momentum, injuries permitting.
Final Prediction and Pick
Seattle's matchup advantages are significant even accounting for the quarterback uncertainty, and Arizona's decimated backfield only adds to Seattle's edge. We lean toward the Seahawks to cover, though bettors should monitor the Darnold injury report closely before kickoff, as a change at quarterback could shift the line. On the total, Arizona's strong over trend combined with two banged-up defenses points toward the over.
For a closer look at Sunday's skill-position volume, be sure to check our Seahawks vs Cardinals player props breakdown for the best individual player bets in this matchup.