49ers vs Cowboys NFL Player Props and DFS Picks

Our 49ers vs Cowboys NFL player props and DFS picks target the best anytime touchdown scorer plays for this Week 10 matchup between the (7-1) San Francisco 49ers and the (4-5) Dallas Cowboys, kicking off Sunday, November 15th at 4:25 PM ET.

For our full spread, moneyline, and total breakdown of this game, check out our 49ers vs Cowboys NFL Picks and Predictions article. You can also see our full Week 10 NFL Schedule for odds and predictions on every game this week.

Below, we're using data from HOF's sports betting research app — including matchup grades and touchdown projections — to make our top anytime touchdown scorer prop picks and DFS plays for this game. We aren't listing specific prop odds here since sportsbook lines for individual player props vary by book, but these are the two players we'd target to find the end zone.

Player Prop Pick #1: C. McCaffrey to Score a Touchdown (SF)

C. McCaffrey leads San Francisco with a 1.3 touchdown projection on 90.9 total yards and carries an A- matchup grade against Dallas' defense, which ranks 32nd against Rush Yards and 24th against Rush TDs. San Francisco ranks 3rd in Rush TDs, which makes McCaffrey the top touchdown candidate for the 49ers, with M. Evans and D. Samuel listed as out.

Player Prop Pick #2: J. Williams to Score a Touchdown (DAL)

J. Williams leads Dallas with a 1.1 touchdown projection on 84 total yards, though he carries a D+ matchup grade against San Francisco's defense, which ranks 2nd against Rush TDs and 4th against Rush Yards. Dallas ranks 6th in Rush TDs, so this is a projection-driven pick, but Williams is the highest-projected skill player on the Cowboys' side, with G. Pickens listed as out.

How We Pick Our 49ers vs Cowboys NFL Player Props and DFS Picks

Our 49ers vs Cowboys NFL player props and DFS picks are built the same way every week: directly from HOF's sports betting research app, not guesswork. We start with HOF's touchdown projections for every skill player involved in the game, then check each player's matchup grade for that game — since a favorable matchup is one of the clearest signals of scoring opportunity.

From there we weigh HOF's projection against the matchup grade for each candidate, which tells us whether the matchup itself favors more or fewer scoring chances. We deliberately don't quote a specific touchdown-scorer prop price here, since sportsbook odds on individual player props vary from book to book and change throughout the week, but the two players we highlight are the ones the data points to as the best bets to find the end zone. We update these picks as HOF's projections and matchup grades change closer to kickoff.

Touchdown scorer props tend to carry more variance than spread or moneyline bets, since a single game script can shut out a projected scorer entirely — which is why we weigh matchup grade alongside the raw projection rather than leaning on touchdown projections alone. A player can hold a strong role and still see the game flow away from him if the score gets out of hand.

For DFS purposes, a strong matchup grade combined with a real projected role tends to correlate with a solid roster floor, since well-matched, featured players are more likely to see the volume needed to pay off even on weeks when they don't find the end zone. Always check HOF's injury report before locking in a lineup, since a late scratch can change the whole picture. We also keep an eye on late-breaking news, since a surprise inactive or a change in a team's depth chart can move a touchdown projection quickly, and we would rather adjust a pick than defend an outdated one.