Seahawks vs Raiders NFL Picks and Predictions

Our Seahawks vs Raiders NFL picks and predictions cover the (5-4) Seattle Seahawks at the (4-5) Las Vegas Raiders on Sunday, November 15th at 4:05 PM ET. Check out our full Week 10 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Seahawks vs Raiders NFL Player Props and DFS Picks article.
Table of Contents
Odds
Seattle is favored at -3.5 (+100) on the spread with a -174 moneyline, while Las Vegas sits at +3.5 (+102) on the spread and +170 on the moneyline. The total is set at 43.5, with the over priced at +100 and the under at -108.
Matchup Breakdown
Seattle's offense has a strong matchup against Las Vegas' defense, ranking 12th in Pass TDs, 15th in Anytime TDs, 16th in Rush+Rec Yards at 331.9, 18th in Pass Yards, 19th in Rush Yards, and 21st in Rush TDs. Las Vegas' defense ranks 26th against Pass Yards, 27th against Rush TDs, 30th against both Rush+Rec Yards and Pass TDs, and 31st against both Anytime TDs and Rush Yards, and D. Lock carries a B+ matchup grade with a projection of 199 passing yards, 1.7 touchdowns, and 0 interceptions, though he is listed as questionable with an oblique injury and S. Darnold is listed as out.
Las Vegas' offense is dangerous through the air but faces a Seattle defense that ranks 1st against Rush+Rec Yards, with the Raiders ranking 2nd in Pass TDs, 3rd in Pass Yards, 10th in Anytime TDs, 12th in Rush+Rec Yards at 342.4, and 31st in both Rush Yards and Rush TDs. Seattle's defense ranks 1st against Rush+Rec Yards at 250.0, 2nd against Pass Yards at 156.0, 5th against Pass TDs, 7th against Rush Yards, 10th against Anytime TDs, and 17th against Rush TDs, and K. Cousins carries an F matchup grade with a projection of 260 passing yards, 2.2 touchdowns, and 0.9 interceptions.
Injury Report
S. Darnold (SEA) – Quadriceps, Out (11/8).
D. Lock (SEA) – Oblique, Questionable (11/8).
R. Shaheed (SEA) – Knee, Out (11/6).
M. Benson (LV) – Coach's Decision, Out (11/8).
A. O'Connell (LV) – Coach's Decision, Out (11/8).
T. Zuhn (LV) – Concussion, Questionable (11/8).
Betting Trends
Seattle has covered the -3 spread in 44% of its games and hit the moneyline in 56%, while Las Vegas has covered the +3 spread in 44% of its games and hit the moneyline in 44%. Seattle holds the better record at 5-4 versus Las Vegas's 4-5.
Our Pick
Pick: Seahawks -3 (-110). Seattle has covered the -3 spread in 44% of its games, as has Las Vegas on the +3, so the trends do not separate these teams, but the matchup grades and rankings do: Seattle's defense ranks 1st against Rush+Rec Yards and K. Cousins carries an F matchup grade, while the Seahawks' offense faces a Raiders defense that ranks 30th or worse against Rush+Rec Yards, Pass TDs, Anytime TDs, and Rush Yards. The risk is the quarterback situation, since D. Lock is questionable and S. Darnold is out.
How We Made Our Seahawks vs Raiders NFL Picks and Predictions
Our Seahawks vs Raiders NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 10 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.