49ers vs Cowboys NFL Picks and Predictions
Our 49ers vs Cowboys NFL picks and predictions cover the (7-1) San Francisco 49ers at the (4-5) Dallas Cowboys on Sunday, November 15th at 4:25 PM ET. Check out our full Week 10 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our 49ers vs Cowboys NFL Player Props and DFS Picks article.
Table of Contents
Odds
San Francisco is favored at -4 (-108) on the spread with a -208 moneyline, while Dallas sits at +4 (-106) on the spread and +199 on the moneyline. The total is set at 55.5, with the over priced at -107 and the under at -103.
Matchup Breakdown
San Francisco's offense has an excellent matchup against Dallas' defense, ranking 2nd in Anytime TDs, 3rd in Rush TDs, 4th in Pass TDs, 6th in Rush+Rec Yards at 371.4, 8th in Rush Yards, and 12th in Pass Yards. Dallas' defense ranks 32nd against both Rush+Rec Yards and Rush Yards, 26th against Anytime TDs, 25th against Pass TDs, 24th against Rush TDs, and 23rd against Pass Yards, and B. Purdy carries a B matchup grade with a projection of 247.5 passing yards, 2.1 touchdowns, and 0.6 interceptions.
Dallas' offense has a balanced profile against San Francisco's defense, ranking 6th in both Anytime TDs and Rush TDs, 9th in Pass Yards, 11th in Pass TDs, 13th in Rush+Rec Yards at 342.0, and 25th in Rush Yards. San Francisco's defense ranks 2nd against Rush TDs, 4th against both Rush+Rec Yards and Rush Yards, 5th against Anytime TDs, 11th against Pass Yards, and 19th against Pass TDs, and D. Prescott carries a D+ matchup grade with a projection of 264.6 passing yards, 1.8 touchdowns, and 0.6 interceptions.
Injury Report
M. Evans (SF) – Tendinitis, Out (11/8).
D. Samuel (SF) – Hamstring, Out (11/6).
B. Aiyuk (SF) – Personal, Out (11/7).
G. Pickens (DAL) – Hamstring, Out (11/8).
K. Turpin (DAL) – Ribs, Out (11/6).
J. Ferguson (DAL) – Knee, Questionable (11/8).
J. Mingo (DAL) – Ankle, Questionable (11/8).
Betting Trends
San Francisco has covered the -4.5 spread in 75% of its games and hit the moneyline in 88%, while Dallas has covered the +4.5 spread in 67% of its games and hit the moneyline in 44%. San Francisco holds the better record at 7-1 versus Dallas's 4-5.
Our Pick
Pick: 49ers -4.5 (+100). San Francisco has covered the -4.5 spread in 75% of its games, while Dallas has covered the +4.5 spread in 67%, but the 49ers' offense ranks 2nd in Anytime TDs against a Cowboys defense that ranks 32nd against both Rush+Rec Yards and Rush Yards. With M. Evans and D. Samuel listed as out, San Francisco's receiving group is thinner, but laying 4.5 points at plus-money against the league's worst Rush Yards defense is the better side.
How We Made Our 49ers vs Cowboys NFL Picks and Predictions
Our 49ers vs Cowboys NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 10 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.