NFL Week 10 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 10 schedule opens with the Washington Commanders visiting the New York Giants on Thursday, Nov. 12, and runs through 14 games before the Los Angeles Chargers visit the Baltimore Ravens on Monday night.

Sunday's slate starts early with Patriots-Lions at 9:30 a.m. ET and includes Chiefs-Falcons, Vikings-Packers, Bills-Jets, Rams-Cardinals, 49ers-Cowboys, and Steelers-Bengals. Several games have tight early spreads, while the Rams, Colts, Bills, and Seahawks stand out among the week's bigger favorites.

Below is the complete NFL schedule for Week 10, followed by an early look at NFL Week 10 odds and predictions. Betting lines are a snapshot and can move significantly before kickoff.

NFL Week 10 Schedule

Here is the Week 10 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• Washington Commanders at New York Giants — Thursday, Nov. 12, 8:15 p.m.
• New England Patriots vs. Detroit Lions — Sunday, Nov. 15, 9:30 a.m.
• Kansas City Chiefs at Atlanta Falcons — Sunday, Nov. 15, 1:00 p.m.
• Houston Texans at Cleveland Browns — Sunday, Nov. 15, 1:00 p.m.
• Minnesota Vikings at Green Bay Packers — Sunday, Nov. 15, 1:00 p.m.
• Miami Dolphins at Indianapolis Colts — Sunday, Nov. 15, 1:00 p.m.
• Carolina Panthers at New Orleans Saints — Sunday, Nov. 15, 1:00 p.m.
• Buffalo Bills at New York Jets — Sunday, Nov. 15, 1:00 p.m.
• Jacksonville Jaguars at Tennessee Titans — Sunday, Nov. 15, 1:00 p.m.
• Los Angeles Rams at Arizona Cardinals — Sunday, Nov. 15, 4:05 p.m.
• Seattle Seahawks at Las Vegas Raiders — Sunday, Nov. 15, 4:05 p.m.
• San Francisco 49ers at Dallas Cowboys — Sunday, Nov. 15, 4:25 p.m.
• Pittsburgh Steelers at Cincinnati Bengals — Sunday, Nov. 15, 8:20 p.m.
• Los Angeles Chargers at Baltimore Ravens — Monday, Nov. 16, 8:15 p.m.

The Week 10 NFL schedule features 14 games. Sunday begins with a 9:30 a.m. ET matchup before seven games in the 1 p.m. window, followed by three late-afternoon games and Steelers-Bengals on Sunday night. Commanders-Giants and Chargers-Ravens provide the standalone Thursday and Monday games.

NFL Week 10 Odds

The early NFL Week 10 odds establish several clear favorites, but there are also a number of games with spreads around a field goal or less. The lines below are based on the supplied odds board and were reviewed Aug. 18, 2026. Because sportsbooks can move their numbers independently, these should be treated as an early betting-market snapshot rather than guaranteed closing lines.

New York is around a 1.5-point favorite against Washington in the Thursday opener, while Detroit is laying roughly 1.5 points against New England. Kansas City is favored by approximately 3.5 points on the road against Atlanta.

Some of the largest Week 10 NFL odds are attached to the Rams, Colts, Bills, and Seahawks. Los Angeles is roughly a 10.5-point favorite at Arizona, making the Rams the largest favorite on the supplied board. Indianapolis is around -7 against Miami, while Buffalo and Seattle are each favored by approximately 6.5 points.

Several games sit in a much tighter range. San Francisco-Dallas is close to a pick'em, with Dallas favored by roughly one point. New York is around -1.5 against Washington, Detroit is approximately -1.5 against New England, and New Orleans is favored by roughly 2.5 points against Carolina.

Totals vary considerably. 49ers-Cowboys carries the highest early total on the supplied board at roughly 53.5 points, while Texans-Browns sits at approximately 36.5. Patriots-Lions also carries a relatively high total around 49.5.

With weeks remaining before kickoff, NFL odds for Week 10 can change because of injuries, roster developments, results from the first half of the season, and betting action. Check current numbers in the Hall of Fame Bets sports betting app before placing a wager.

NFL Week 10 Predictions

Early NFL Week 10 predictions should be treated differently from the schedule and betting lines: these are analytical leans, not factual outcomes or guarantees.

Commanders at Giants: New York gets the early lean. The Giants are favored by roughly 1.5 points at home, making the Thursday opener one of the closest games on the Week 10 board.

Patriots vs. Lions: Detroit gets a slight nod. The Lions are favored by approximately 1.5 points, while the total near 50 points suggests the early market sees meaningful scoring potential.

Chiefs at Falcons: Kansas City gets the prediction. The Chiefs are favored by around 3.5 points on the road, giving them a modest early advantage over Atlanta.

Texans at Browns: Houston gets the early pick. The Texans are favored by roughly 4.5 points, while the 36.5-point total makes this the lowest-scoring projection on the supplied Week 10 board.

Vikings at Packers: Green Bay gets the prediction. The Packers are favored by approximately 4.5 points at home, giving them a meaningful early advantage in the divisional matchup.

Dolphins at Colts: Indianapolis gets the pick. The Colts are favored by roughly seven points at home, putting them among the stronger Week 10 favorites.

Panthers at Saints: New Orleans gets the early lean. The Saints are favored by approximately 2.5 points at home, leaving Carolina within upset range according to the early market.

Bills at Jets: Buffalo gets the prediction. The Bills are favored by roughly 6.5 points on the road, giving them one of the more substantial early advantages of Week 10.

Jaguars at Titans: Jacksonville gets the pick. The Jaguars are favored by around three points on the road, with the early market expecting a relatively competitive divisional matchup.

Rams at Cardinals: Los Angeles gets the prediction. The Rams are favored by approximately 10.5 points, making them the largest favorite on the supplied Week 10 odds board.

Seahawks at Raiders: Seattle gets the early pick. The Seahawks are favored by roughly 6.5 points on the road, putting them among the week's stronger favorites.

49ers at Cowboys: Dallas gets a narrow lean. The Cowboys are favored by approximately one point at home, making this essentially a toss-up, while the 53.5-point total is the highest on the early Week 10 board.

Steelers at Bengals: Cincinnati gets the Sunday night prediction. The Bengals are favored by roughly 4.5 points at home, giving them a meaningful early advantage in the divisional matchup.

Chargers at Ravens: Baltimore gets the Monday night lean. The Ravens are favored by approximately three points at home, but the modest spread suggests a competitive Week 10 finale.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 10?

Based on the supplied early NFL Week 10 odds, the Rams are the biggest favorite, laying roughly 10.5 points against the Cardinals. Indianapolis follows at around -7 against Miami, while Buffalo and Seattle are each favored by approximately 6.5 points.

Green Bay, Cincinnati, and Houston are also favored by roughly 4.5 points. At the opposite end of the spectrum, 49ers-Cowboys is essentially a toss-up, while Commanders-Giants and Patriots-Lions have spreads around 1.5 points.

Being favored does not mean a team is predicted to win with certainty. Point spreads reflect the betting market and can change substantially between the opening numbers and kickoff.

What Are the Odds for NFL Week 10?

NFL Week 10 odds include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for the combined points scored by both teams.

For Week 10 of the 2026 season, the supplied odds show a wide range of expectations. The Rams are favored by roughly 10.5 points against Arizona, while Dallas is only around a one-point favorite against San Francisco. Commanders-Giants and Patriots-Lions also feature spreads of less than a field goal.

Totals vary significantly across the Week 10 NFL schedule. 49ers-Cowboys sits at approximately 53.5 points, the highest number on the supplied board, while Texans-Browns is down around 36.5.

Bettors on our sports betting app should compare the latest market before making a decision because these early numbers can move as Week 10 approaches.

Who Is Predicted to Win Week 10 in the NFL?

Our early Week 10 NFL predictions lean toward the Giants, Detroit, Kansas City, Houston, Green Bay, Indianapolis, New Orleans, Buffalo, Jacksonville, the Rams, Seattle, Dallas, Cincinnati, and Baltimore.

Those selections are preliminary. Results from the first half of the season, injuries, roster changes, depth-chart decisions, and updated betting markets can alter the analysis before kickoff.

The Week 10 schedule offers a mix of close games and substantial favorites, with Commanders-Giants opening the week and Chargers-Ravens closing it on Monday night. As kickoff approaches, updated NFL Week 10 odds and matchup-specific analysis will provide a clearer picture of where the strongest predictions and betting opportunities may be.