Dolphins vs 49ers NFL Player Props and DFS Picks

Looking for the best Dolphins vs 49ers player props for Sunday's Week 2 matchup? We break down usage rates, target share, and matchup grades for the key skill players on both sides to help you build your DFS lineup and prop card. Check out our full Week 2 NFL Schedule for odds and predictions on every game this week.
You can dig deeper into usage share, target rates, and matchup grades yourself with our sports betting research app, which we used to pull every number in this breakdown.
Table of Contents
Dolphins vs 49ers QB Props
San Francisco's Brock Purdy carries a C+ Matchup grade for Sunday, projected for 220.3 passing yards, 2 touchdowns, and 1 interception, giving him solid touchdown equity in a game his team is favored to control.
Miami's projected starter Malik Willis carries a matching C+ Matchup grade but a much lighter statistical outlook, projected for just 105.5 passing yards, 0.8 touchdowns, and 0 interceptions, suggesting a run-heavy approach for the Dolphins in a game they're expected to trail.
Dolphins vs 49ers RB and TE Props
Miami's De'Von Achane leads all skill players in this matchup with a projection of 128.3 total yards and 0.7 touchdowns on a C+ Matchup grade, making him a strong floor play even in a difficult game script.
San Francisco's Christian McCaffrey carries an A- Matchup grade, projected for 109.2 total yards and 1.1 touchdowns, while George Kittle also grades out at A-, projected for 66.8 total yards and 0.6 touchdowns.
Dolphins vs 49ers Usage Share Breakdown
Miami's target distribution is led by De'Von Achane at 19.5% (5.3 targets per game), followed by Malik Washington at 14.1% (3.8 targets) and Gavin Dulcich at 15.1% (3.7 targets). No single Dolphins pass catcher commands an overwhelming share, spreading opportunity across the depth chart.
San Francisco's passing game is led by Christian McCaffrey at 23.6% (7.5 targets) and George Kittle at 20.3% (5.9 targets). Ricky Pearsall's 17.7% share (5.6 targets) is off the board with him ruled out, which should mean more volume for Jake Tonges (13.3%, 4.6 targets) and Demarcus Robinson (8.7%, 2.7 targets).
Dolphins vs 49ers Injury Impact on Props
San Francisco's receiving corps is dealing with real attrition heading into Sunday, with Ricky Pearsall, Christian Kirk, and Brandon Aiyuk all ruled out. That leaves Christian McCaffrey, George Kittle, Jake Tonges, and Demarcus Robinson as the primary beneficiaries of the extra target volume. Miami did not have any players listed on the injury report.
Best Dolphins vs 49ers Player Prop Picks
Our top plays for this matchup lean toward the players positioned to benefit most from San Francisco's receiver injuries: Christian McCaffrey and George Kittle both carry strong matchup grades and should see a target bump, while De'Von Achane offers a solid floor for Miami even in a tough spot. For the full game outlook, be sure to check our Dolphins vs 49ers picks for our against-the-spread and total recommendations.