Lions vs Bills NFL Player Props and DFS Picks

Thursday Night Football kicks off NFL Week 2 with a full slate of Lions vs Bills player props spanning the passing, rushing, and receiving markets. Using HOF's player projection and usage-share data, here's a matchup-specific breakdown of the best player props and DFS picks for Detroit and Buffalo — and for the rest of the week's games, check out our Week 2 NFL Schedule.

Lions vs Bills Player Props Overview

Detroit and Buffalo both rank inside the top five leaguewide in anytime touchdown rate, and the 52.5 total is one of the highest marks on the Week 2 board, pointing to real value across the Lions vs Bills prop bets and Lions vs Bills props markets alike. Before locking in any Lions vs Bills DFS picks, compare current numbers on a sports betting research app, since prop pricing tends to move more than the point spread as kickoff approaches.

Quarterback Props: Goff vs Allen

Jared Goff projects for 293.3 passing yards, 1.9 touchdowns, and 0.5 interceptions in HOF's data, one of the higher yardage projections on the Week 2 board despite carrying a difficult matchup grade against Buffalo's defense — a sign the model expects Detroit to be throwing often to keep pace. Josh Allen's projection of 231.7 passing yards, 1.6 touchdowns, and 0.8 interceptions is lower in yardage but comes with a friendlier matchup grade, and the elevated interception number is worth a look for turnover-based props.

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Running Back Props: Gibbs vs Cook

Jahmyr Gibbs is projected for 111.9 total yards and 1.1 touchdowns with a favorable matchup grade, making him one of the stronger anytime-touchdown and rushing-yardage plays on Thursday's board. James Cook checks in lower at 106 total yards and 0.7 touchdowns in a tougher spot, while Buffalo's Ray Davis (55.3 total yards, 0.2 touchdowns) profiles best as a touch-share flex option rather than a primary DFS play.

Receiver and Target Share Props

Amon-Ra St. Brown leads the entire matchup in usage with a 31.3% target share (10.1 targets per game), giving him one of the higher receptions-prop floors in the game even though his individual matchup grade is difficult; Jameson Williams (18.4% share, 83.9 projected total yards) is the next man up in Detroit's passing attack. Buffalo's Khalil Shakir paces the Bills with a 22.1% target share and the best matchup grade among the team's pass catchers, projected for 46.6 total yards, while Dalton Kincaid (14.7%) and Keon Coleman (14.3%) round out a receiving corps that's more spread out than Detroit's. That distribution makes Shakir the steadier volume-based prop, while Kincaid and Coleman carry more touchdown-dependent upside.

Best Lions vs Bills DFS Picks

Looking for the best player props for Lions vs Bills across cash games and tournaments? Amon-Ra St. Brown's target share and Jahmyr Gibbs' favorable matchup grade make them the safer volume-based plays in this matchup, while Khalil Shakir offers a similar floor for Buffalo. In tournaments, Jameson Williams' big-play role and Buffalo's questionable-tagged pass catchers, T. Johnson (lower leg) and J. Hancock (quadriceps), are worth monitoring into kickoff, since either absence would push more volume toward Shakir and Kincaid.

For the full matchup-wide betting angles, team trends, and injury report, read our Lions vs Bills picks breakdown as well.