NFL Week 4 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 4 schedule opens with the Pittsburgh Steelers visiting the Cleveland Browns on Thursday, Oct. 1, and runs through 16 games before the Atlanta Falcons visit the New Orleans Saints on Monday night.

Sunday's slate starts early with Colts-Commanders at 9:30 a.m. ET and includes Patriots-Bills, Jaguars-Bengals, Broncos-49ers, Chiefs-Raiders, and Lions-Panthers. Several games have tight early spreads, while Baltimore, Chicago, and Minnesota stand out among the week's biggest favorites.

Below is the complete NFL schedule for Week 4, followed by an early look at NFL Week 4 odds and predictions. Betting lines are a snapshot and can move significantly before kickoff.

NFL Week 4 Schedule

Here is the Week 4 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• Pittsburgh Steelers at Cleveland Browns — Thursday, Oct. 1, 8:15 p.m.
• Indianapolis Colts vs. Washington Commanders — Sunday, Oct. 4, 9:30 a.m.
• New England Patriots at Buffalo Bills — Sunday, Oct. 4, 1:00 p.m.
• Jacksonville Jaguars at Cincinnati Bengals — Sunday, Oct. 4, 1:00 p.m.
• Green Bay Packers at Tampa Bay Buccaneers — Sunday, Oct. 4, 1:00 p.m.
• Tennessee Titans at Baltimore Ravens — Sunday, Oct. 4, 1:00 p.m.
• Los Angeles Rams at Philadelphia Eagles — Sunday, Oct. 4, 1:00 p.m.
• Arizona Cardinals at New York Giants — Sunday, Oct. 4, 1:00 p.m.
• New York Jets at Chicago Bears — Sunday, Oct. 4, 1:00 p.m.
• Dallas Cowboys at Houston Texans — Sunday, Oct. 4, 1:00 p.m.
• Miami Dolphins at Minnesota Vikings — Sunday, Oct. 4, 4:05 p.m.
• Denver Broncos at San Francisco 49ers — Sunday, Oct. 4, 4:25 p.m.
• Kansas City Chiefs at Las Vegas Raiders — Sunday, Oct. 4, 4:25 p.m.
• Los Angeles Chargers at Seattle Seahawks — Sunday, Oct. 4, 4:25 p.m.
• Detroit Lions at Carolina Panthers — Sunday, Oct. 4, 8:20 p.m.
• Atlanta Falcons at New Orleans Saints — Monday, Oct. 5, 8:15 p.m.

The Week 4 NFL schedule is concentrated on Sunday, beginning with a 9:30 a.m. ET game before seven matchups in the 1 p.m. window. Four late-afternoon games follow, with Lions-Panthers in prime time. Steelers-Browns and Falcons-Saints provide the week's standalone Thursday and Monday games.

NFL Week 4 Odds

The early NFL Week 4 odds establish several clear favorites, but there are also a number of games with spreads around a field goal or less. The lines below are based on the supplied odds board and were reviewed Aug. 17, 2026. Because sportsbooks can move their numbers independently, these should be treated as an early betting-market snapshot rather than guaranteed closing lines.

Pittsburgh is around a 2.5-point favorite against Cleveland, while Indianapolis-Washington is effectively priced as a toss-up. Buffalo is laying roughly three points against New England, and Cincinnati is favored by approximately 2.5 points over Jacksonville.

Some of the largest Week 4 NFL odds are attached to Baltimore, Chicago, and Minnesota. The Ravens are roughly 8.5-point favorites against Tennessee, Chicago is around -8.5 against the Jets, and Minnesota is favored by approximately seven points over Miami.

Several games sit in a much tighter range. Green Bay is around -1.5 against Tampa Bay, the Rams are roughly -1.5 at Philadelphia, and Houston is favored by approximately 2.5 points against Dallas. San Francisco, Seattle, and New Orleans are also favored by around a field goal or less.

Totals vary considerably. Jaguars-Bengals carries one of the highest early totals at roughly 51.5 points, while Steelers-Browns is sitting around 40.5. Patriots-Bills is another relatively high-total matchup at approximately 50.5.

With weeks remaining before kickoff, NFL odds for Week 4 can change because of injuries, roster developments, early-season performance, and betting action. Check current numbers in the Hall of Fame Bets sports betting app before placing a wager.

NFL Week 4 Predictions

Early NFL Week 4 predictions should be treated differently from the schedule and betting lines: these are analytical leans, not factual outcomes or guarantees.

Steelers at Browns: Pittsburgh gets the early lean. The Steelers are favored by roughly 2.5 points on the road, but the small spread suggests the market expects a competitive AFC North matchup.

Colts vs. Commanders: Indianapolis gets a slight nod. The moneyline is close to even and the spread is effectively a pick'em, making this one of the most difficult Week 4 games to separate based on the early market.

Patriots at Bills: Buffalo gets the prediction. The Bills are favored by around three points at home, while the total near 50 points points toward the potential for a higher-scoring matchup.

Jaguars at Bengals: Cincinnati gets the early pick. The Bengals are favored by approximately 2.5 points at home, and the elevated total makes this one of Week 4's higher-scoring projections.

Packers at Buccaneers: Green Bay gets a narrow lean. The Packers are favored by roughly 1.5 points on the road, leaving little separation between these teams in the early odds.

Titans at Ravens: Baltimore gets the prediction. The Ravens are favored by approximately 8.5 points at home, making them one of the strongest favorites on the Week 4 board.

Rams at Eagles: Los Angeles gets the early lean. The Rams are favored by around 1.5 points on the road, although the modest spread keeps Philadelphia firmly within upset range.

Cardinals at Giants: New York gets the pick. The Giants are favored by roughly 6.5 points at home, giving them one of the more substantial early advantages in Sunday's 1 p.m. window.

Jets at Bears: Chicago gets the prediction. The Bears are favored by approximately 8.5 points at home, putting them alongside Baltimore among the week's biggest favorites.

Cowboys at Texans: Houston gets the early lean. The Texans are favored by roughly 2.5 points at home in another matchup the market expects to remain competitive.

Dolphins at Vikings: Minnesota gets the pick. The Vikings are favored by around seven points at home, giving them a sizable early advantage over Miami.

Broncos at 49ers: San Francisco gets the prediction. The 49ers are favored by approximately 2.5 points at home, but the relatively tight spread suggests Denver is being given considerable respect by the early market.

Chiefs at Raiders: Kansas City gets the early lean. The Chiefs are favored by roughly 5.5 points on the road, making them one of Sunday's stronger visiting favorites.

Chargers at Seahawks: Seattle gets the pick. The Seahawks are favored by around three points at home, with the early line suggesting a competitive matchup.

Lions at Panthers: Detroit gets the prediction. The Lions are favored by approximately three points on the road in the Sunday night matchup, leaving Carolina within striking distance according to the early market.

Falcons at Saints: New Orleans gets the Monday night lean. The Saints are favored by roughly 2.5 points at home, making this another Week 4 matchup with relatively little separation.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 4?

Based on the supplied early NFL Week 4 odds, the Ravens and Bears are the biggest favorites, each laying roughly 8.5 points. Baltimore is favored over Tennessee, while Chicago is favored against the Jets. Minnesota follows at approximately -7 against Miami, with the Giants around -6.5 against Arizona.

Kansas City is also favored by more than a field goal against Las Vegas. At the opposite end of the spectrum, Colts-Commanders is essentially a toss-up, while Packers-Buccaneers and Rams-Eagles have spreads around 1.5 points.

Being favored does not mean a team is predicted to win with certainty. Point spreads reflect the betting market and can change substantially between the opening numbers and kickoff.

What Are the Odds for NFL Week 4?

NFL Week 4 odds include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for the combined points scored by both teams.

For Week 4 of the 2026 season, the supplied odds show a wide range of expectations. Baltimore and Chicago are favored by roughly 8.5 points, while Indianapolis-Washington is priced close to a pick'em. Green Bay-Tampa Bay and Rams-Philadelphia are also separated by less than a field goal.

Totals vary across the Week 4 NFL schedule. Jaguars-Bengals sits around 51.5 points, while Steelers-Browns is around 40.5. Patriots-Bills is also among the higher totals at approximately 50.5.

Bettors should compare the latest market before making a decision because these early numbers can move as Week 4 approaches. You can use our sports betting app to help you make informed betting decisions for week 4.

Who Is Predicted to Win Week 4 in the NFL?

Our early Week 4 NFL predictions lean toward Pittsburgh, Indianapolis, Buffalo, Cincinnati, Green Bay, Baltimore, the Rams, the Giants, Chicago, Houston, Minnesota, San Francisco, Kansas City, Seattle, Detroit, and New Orleans.

Those selections are preliminary. Results from the opening weeks, injuries, roster changes, depth-chart decisions, and updated betting markets can alter the analysis before kickoff.

The Week 4 schedule offers a mix of close games and substantial favorites, with Steelers-Browns opening the week and Falcons-Saints closing it on Monday night. As kickoff approaches, updated NFL Week 4 odds and matchup-specific analysis will provide a clearer picture of where the strongest predictions and betting opportunities may be.