NFL Week 1 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 1 schedule opens with a Super Bowl rematch and runs through a full slate of 16 games spread across Wednesday, Thursday, Sunday, and Monday.

New England visits defending champion Seattle in the season opener on Wednesday, Sept. 9, before the 49ers and Rams meet in Melbourne, Australia, on Thursday. Sunday brings 13 games, including Commanders-Eagles and Cowboys-Giants, while Broncos-Chiefs closes Week 1 on Monday night. The NFL's official schedule confirms the opening-week dates and matchups.

Below is the complete NFL schedule for Week 1, followed by an early look at NFL Week 1 odds and predictions. Betting lines are a snapshot and can move significantly before kickoff.

NFL Week 1 Schedule

Here is the Week 1 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• New England Patriots at Seattle Seahawks — Wednesday, Sept. 9, 8:20 p.m.
• San Francisco 49ers vs. Los Angeles Rams — Thursday, Sept. 10, 8:35 p.m. (Melbourne, Australia)
• Tampa Bay Buccaneers at Cincinnati Bengals — Sunday, Sept. 13, 1:00 p.m.
• Baltimore Ravens at Indianapolis Colts — Sunday, Sept. 13, 1:00 p.m.
• Buffalo Bills at Houston Texans — Sunday, Sept. 13, 1:00 p.m.
• New Orleans Saints at Detroit Lions — Sunday, Sept. 13, 1:00 p.m.
• Cleveland Browns at Jacksonville Jaguars — Sunday, Sept. 13, 1:00 p.m.
• New York Jets at Tennessee Titans — Sunday, Sept. 13, 1:00 p.m.
• Atlanta Falcons at Pittsburgh Steelers — Sunday, Sept. 13, 1:00 p.m.
• Chicago Bears at Carolina Panthers — Sunday, Sept. 13, 1:00 p.m.
• Green Bay Packers at Minnesota Vikings — Sunday, Sept. 13, 4:25 p.m.
• Washington Commanders at Philadelphia Eagles — Sunday, Sept. 13, 4:25 p.m.
• Arizona Cardinals at Los Angeles Chargers — Sunday, Sept. 13, 4:25 p.m.
• Miami Dolphins at Las Vegas Raiders — Sunday, Sept. 13, 4:25 p.m.
• Dallas Cowboys at New York Giants — Sunday, Sept. 13, 8:20 p.m.
• Denver Broncos at Kansas City Chiefs — Monday, Sept. 14, 8:15 p.m.

The unusual opening-week format puts two major games ahead of the traditional Sunday slate. Patriots-Seahawks is a rematch of Super Bowl LX, while 49ers-Rams will be the NFL's first regular-season game in Australia.

NFL Week 1 Odds

The early NFL Week 1 odds establish several clear favorites, but there are also a number of games with spreads around a field goal or less. The lines below are based on the supplied odds board and were reviewed Aug. 17, 2026. Because sportsbooks can move their numbers independently, these should be treated as an early betting-market snapshot rather than guaranteed closing lines.

Seattle is around a 3.5-point favorite against New England, while the Rams are laying roughly 3.5 points against the 49ers. Cincinnati is also around -3.5 against Tampa Bay.

Some of the largest Week 1 NFL odds are attached to Detroit, Jacksonville, and the Chargers. The Lions are roughly 6.5-point favorites over New Orleans, Jacksonville is around -7 against Cleveland, and Los Angeles is approximately a 9.5-point favorite against Arizona.

Several games sit in a much tighter range. Buffalo-Houston is around Texans +1.5, Packers-Vikings is close to a one-point spread, and Denver-Kansas City has the Chiefs favored by roughly 2.5 points. Those narrower numbers indicate games in which the early market sees relatively little separation.

Totals also vary considerably. Tampa Bay-Cincinnati carries one of the highest early totals at roughly 51.5 points, while Jets-Titans is sitting around 40.5.

With weeks remaining before kickoff, NFL odds for Week 1 can change because of injuries, roster developments, preseason performance, and betting action. Check current numbers in the Hall of Fame Bets sports betting app before placing a wager.

NFL Week 1 Predictions

Early NFL Week 1 predictions should be treated differently from the schedule and betting lines: these are analytical leans, not factual outcomes or guarantees.

Patriots at Seahawks: Seattle gets the early lean. The Seahawks open their title defense at home and are favored by around a field goal, although the Super Bowl rematch makes this one of Week 1's most closely watched games.

49ers vs. Rams: Los Angeles is the early pick in Melbourne. The Rams enter as a modest favorite in a divisional matchup that could be much tighter than the venue and unusual travel circumstances make it appear.

Buccaneers at Bengals: Cincinnati gets the nod. The Bengals are laying around 3.5 points, and the high total suggests the market expects one of the more offense-friendly games on the Week 1 schedule.

Ravens at Colts: Baltimore is the early prediction. The Ravens are favored on the road, but a spread around a field goal keeps Indianapolis firmly in upset territory.

Bills at Texans: Buffalo gets a slight lean in what the early line effectively treats as a near toss-up. This is one of the Week 1 games where taking a strong position months before kickoff carries added uncertainty.

Saints at Lions: Detroit is the pick. A spread approaching a touchdown makes the Lions one of the clearer favorites on the Week 1 NFL schedule.

Browns at Jaguars: Jacksonville gets the early prediction. The Jaguars are around a touchdown favorite, putting them among the largest favorites of opening week.

Jets at Titans: Tennessee gets the lean in another relatively competitive matchup. With the spread under a field goal, there is little room for error in either direction.

Falcons at Steelers: Pittsburgh is the pick. The Steelers have home field and an early line around a field goal, but the market isn't pricing this as a mismatch.

Bears at Panthers: Chicago gets a narrow lean. This matchup is one of the more difficult early games to call, with neither side receiving the kind of market support seen with Week 1's biggest favorites.

Packers at Vikings: Minnesota gets a slight edge, but this is essentially a toss-up based on the early odds. Divisional familiarity adds another reason to be cautious about drawing too much from a one-point spread.

Commanders at Eagles: Philadelphia is the early prediction. The Eagles are favored by more than a field goal at home, giving them one of the stronger positions among Sunday's late-afternoon favorites.

Cardinals at Chargers: Los Angeles is the pick. The Chargers have the largest spread on the supplied board at roughly 9.5 points, making them the market's strongest Week 1 favorite at this stage.

Dolphins at Raiders: Las Vegas gets the lean. The Raiders are favored by around 3.5 points at home in a matchup carrying one of the lower totals of Week 1.

Cowboys at Giants: Dallas gets the early prediction. The Cowboys are modest road favorites, but the three-point range leaves the Giants within striking distance in the Sunday night matchup.

Broncos at Chiefs: Kansas City gets the lean in the Week 1 finale. The Chiefs are only a small home favorite, making Broncos-Chiefs another matchup where the early market anticipates a competitive game.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 1?

Based on the supplied early NFL Week 1 odds, the Chargers are the biggest favorite, laying roughly 9.5 points against the Cardinals. Jacksonville is around a seven-point favorite over Cleveland, while Detroit is favored by approximately 6.5 over New Orleans.

Philadelphia is also favored by more than a field goal against Washington. At the opposite end of the spectrum, Bills-Texans and Packers-Vikings are among the closest games on the board.

Being favored does not mean a team is predicted to win with certainty. Point spreads reflect the betting market and can change substantially between the opening numbers and kickoff.

What Are the Odds for NFL Week 1?

NFL Week 1 odds include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for the combined points scored by both teams.

For the 2026 opener, the supplied odds show a wide range of expectations. Some matchups have favorites of a touchdown or more, while others are separated by only one to three points. Bettors should compare the latest market before making a decision because these early numbers are likely to move as Week 1 approaches.

Who Is Predicted to Win Week 1 in the NFL?

Our early Week 1 NFL predictions lean toward Seattle, the Rams, Cincinnati, Baltimore, Buffalo, Detroit, Jacksonville, Tennessee, Pittsburgh, Chicago, Minnesota, Philadelphia, the Chargers, Las Vegas, Dallas, and Kansas City.

Those selections are preliminary. Week 1 is still several weeks away, and injuries, roster changes, depth-chart decisions, and updated betting markets can alter the analysis before kickoff in our sports betting app.

The schedule itself is set, however, and Week 1 already offers a strong mix of rematches, divisional games, prime-time matchups, and the league's first regular-season game in Australia. As kickoff approaches, the combination of updated NFL Week 1 odds and matchup-specific analysis will provide a clearer picture of where the strongest predictions and betting opportunities may be.