NFL Week 5 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 5 schedule opens with the Tampa Bay Buccaneers visiting the Dallas Cowboys on Thursday, Oct. 8, and runs through 14 games before the Buffalo Bills visit the Los Angeles Rams on Monday night.

Sunday's slate starts early with Eagles-Jaguars at 9:30 a.m. ET and includes Bengals-Dolphins, Lions-Cardinals, 49ers-Seahawks, and Ravens-Falcons. Several games have tight early spreads, while New England and Detroit stand out among the week's biggest favorites.

Below is the complete NFL schedule for Week 5, followed by an early look at NFL Week 5 odds and predictions. Betting lines are a snapshot and can move significantly before kickoff.

NFL Week 5 Schedule

Here is the Week 5 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• Tampa Bay Buccaneers at Dallas Cowboys — Thursday, Oct. 8, 8:15 p.m.
• Philadelphia Eagles at Jacksonville Jaguars — Sunday, Oct. 11, 9:30 a.m.
• Cincinnati Bengals at Miami Dolphins — Sunday, Oct. 11, 1:00 p.m.
• Las Vegas Raiders at New England Patriots — Sunday, Oct. 11, 1:00 p.m.
• Minnesota Vikings at New Orleans Saints — Sunday, Oct. 11, 1:00 p.m.
• Cleveland Browns at New York Jets — Sunday, Oct. 11, 1:00 p.m.
• Indianapolis Colts at Pittsburgh Steelers — Sunday, Oct. 11, 1:00 p.m.
• Houston Texans at Tennessee Titans — Sunday, Oct. 11, 1:00 p.m.
• New York Giants at Washington Commanders — Sunday, Oct. 11, 1:00 p.m.
• Denver Broncos at Los Angeles Chargers — Sunday, Oct. 11, 4:05 p.m.
• Detroit Lions at Arizona Cardinals — Sunday, Oct. 11, 4:25 p.m.
• Chicago Bears at Green Bay Packers — Sunday, Oct. 11, 4:25 p.m.
• San Francisco 49ers at Seattle Seahawks — Sunday, Oct. 11, 4:25 p.m.
• Baltimore Ravens at Atlanta Falcons — Sunday, Oct. 11, 8:20 p.m.
• Buffalo Bills at Los Angeles Rams — Monday, Oct. 12, 8:15 p.m.

The Week 5 NFL schedule is lighter than the opening weeks of the season, with 15 games on the slate. Sunday begins with a 9:30 a.m. ET matchup before seven games in the 1 p.m. window, followed by four late-afternoon games and Ravens-Falcons on Sunday night. Buccaneers-Cowboys and Bills-Rams provide the standalone Thursday and Monday games.

NFL Week 5 Odds

The early NFL Week 5 odds establish several clear favorites, but there are also a number of games with spreads around a field goal or less. The lines below are based on the supplied odds board and were reviewed Aug. 17, 2026. Because sportsbooks can move their numbers independently, these should be treated as an early betting-market snapshot rather than guaranteed closing lines.

Dallas is around a three-point favorite against Tampa Bay, while Philadelphia is laying roughly 1.5 points against Jacksonville. Cincinnati is also a sizable road favorite, laying approximately six points against Miami.

Some of the largest Week 5 NFL odds are attached to New England and Detroit. The Patriots are roughly 8.5-point favorites against Las Vegas, while the Lions are favored by approximately eight points on the road against Arizona. Cincinnati is around -6 against Miami.

Several games sit in a much tighter range. Minnesota-New Orleans is effectively a toss-up, Pittsburgh is favored by around two points against Indianapolis, and the Chargers are roughly -2.5 against Denver. Washington and the Jets are also favored by approximately 2.5 points.

Totals vary considerably. Bills-Rams carries one of the highest early totals at roughly 54.5 points, while Browns-Jets sits at approximately 39.5. Buccaneers-Cowboys is another relatively high-total matchup, with the supplied board showing numbers in the low 50s.

With weeks remaining before kickoff, NFL odds for Week 5 can change because of injuries, roster developments, early-season performance, and betting action. Check current numbers in the Hall of Fame Bets sports betting app before placing a wager.

NFL Week 5 Predictions

Early NFL Week 5 predictions should be treated differently from the schedule and betting lines: these are analytical leans, not factual outcomes or guarantees.

Buccaneers at Cowboys: Dallas gets the early lean. The Cowboys are favored by around three points at home, while the total above 50 points suggests the early market sees the potential for significant scoring.

Eagles at Jaguars: Philadelphia gets a slight nod. The Eagles are favored by roughly 1.5 points, making this one of the closest games on the Week 5 board.

Bengals at Dolphins: Cincinnati is the early pick. The Bengals are favored by approximately six points on the road, giving them one of the stronger early market positions of the week.

Raiders at Patriots: New England gets the prediction. The Patriots are favored by roughly 8.5 points at home, making them the biggest favorite on the supplied Week 5 board.

Vikings at Saints: Minnesota gets a narrow lean. The moneyline and spread are close to even, so there is little separation between these teams in the early market.

Browns at Jets: New York gets the pick. The Jets are favored by approximately 2.5 points at home, but the modest spread and low total suggest a potentially close game.

Colts at Steelers: Pittsburgh gets the early prediction. The Steelers are favored by around two points at home, leaving Indianapolis firmly within upset range.

Texans at Titans: Houston gets the lean. The Texans are favored by roughly three points on the road, giving them a modest early advantage.

Giants at Commanders: Washington gets the pick. The Commanders are favored by approximately 2.5 points at home in another matchup the early market expects to remain competitive.

Broncos at Chargers: Los Angeles gets the prediction. The Chargers are favored by roughly 2.5 points at home, but the narrow line suggests the market sees relatively little separation.

Lions at Cardinals: Detroit gets the early pick. The Lions are favored by around eight points on the road, placing them among Week 5's strongest favorites.

Bears at Packers: Green Bay gets the lean. The Packers are favored by approximately three points at home, with the early market anticipating a competitive divisional matchup.

49ers at Seahawks: Seattle gets the prediction. The Seahawks are favored by roughly 3.5 points at home, giving them a modest edge in another divisional game.

Ravens at Falcons: Baltimore gets the early pick. The Ravens are favored by approximately four points on the road, while the relatively high total points toward the potential for an offense-driven Sunday night matchup.

Bills at Rams: Los Angeles gets the Monday night lean. The Rams are favored by roughly three points at home, and the total above 50 points makes this one of the highest-scoring projections of Week 5.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 5?

Based on the supplied early NFL Week 5 odds, the Patriots are the biggest favorite, laying roughly 8.5 points against the Raiders. Detroit is around an eight-point favorite over Arizona, while Cincinnati is favored by approximately six points against Miami.

Baltimore is also favored by around four points against Atlanta. At the opposite end of the spectrum, Vikings-Saints is essentially a toss-up, while Eagles-Jaguars and Colts-Steelers are separated by roughly two points or less.

Being favored does not mean a team is predicted to win with certainty. Point spreads reflect the betting market and can change substantially between the opening numbers and kickoff.

What Are the Odds for NFL Week 5?

NFL Week 5 odds include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for the combined points scored by both teams.

For Week 5 of the 2026 season, the supplied odds show a wide range of expectations. New England is favored by roughly 8.5 points against Las Vegas, while Minnesota-New Orleans is essentially priced as a pick'em. Philadelphia-Jacksonville and Indianapolis-Pittsburgh are also separated by only a couple of points.

Totals vary across the Week 5 NFL schedule. Bills-Rams is among the highest at roughly 54.5 points, while Browns-Jets sits around 39.5.

Bettors should compare the latest market before making a decision because these early numbers can move as Week 5 approaches.

Who Is Predicted to Win Week 5 in the NFL?

Our early Week 5 NFL predictions lean toward Dallas, Philadelphia, Cincinnati, New England, Minnesota, the Jets, Pittsburgh, Houston, Washington, the Chargers, Detroit, Green Bay, Seattle, Baltimore, and the Rams.

Those selections are preliminary. Results from the opening weeks, injuries, roster changes, depth-chart decisions, and updated betting markets can alter the analysis before kickoff.

The Week 5 schedule offers a mix of close games and substantial favorites, with Buccaneers-Cowboys opening the week and Bills-Rams closing it on Monday night. As kickoff approaches, updated NFL Week 5 odds and matchup-specific analysis will provide a clearer picture of where the strongest predictions and betting opportunities may be.