NFL Week 6 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 6 schedule opens with the Seattle Seahawks visiting the Denver Broncos on Thursday, Oct. 15, and runs through 14 games before the Washington Commanders visit the San Francisco 49ers on Monday night.

Sunday's slate starts early with Texans-Jaguars at 9:30 a.m. ET and includes Ravens-Browns, Panthers-Eagles, Chargers-Chiefs, Bills-Raiders, and Cowboys-Packers. Several games have tight early spreads, while the Rams and Patriots stand out among the week's biggest favorites.

Below is the complete NFL schedule for Week 6, followed by an early look at NFL Week 6 odds and predictions. Betting lines are a snapshot and can move significantly before kickoff.

NFL Week 6 Schedule

Here is the Week 6 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• Seattle Seahawks at Denver Broncos — Thursday, Oct. 15, 8:15 p.m.
• Houston Texans vs. Jacksonville Jaguars — Sunday, Oct. 18, 9:30 a.m.
• Chicago Bears at Atlanta Falcons — Sunday, Oct. 18, 1:00 p.m.
• Baltimore Ravens at Cleveland Browns — Sunday, Oct. 18, 1:00 p.m.
• Tennessee Titans at Indianapolis Colts — Sunday, Oct. 18, 1:00 p.m.
• New York Jets at New England Patriots — Sunday, Oct. 18, 1:00 p.m.
• New Orleans Saints at New York Giants — Sunday, Oct. 18, 1:00 p.m.
• Carolina Panthers at Philadelphia Eagles — Sunday, Oct. 18, 1:00 p.m.
• Pittsburgh Steelers at Tampa Bay Buccaneers — Sunday, Oct. 18, 1:00 p.m.
• Arizona Cardinals at Los Angeles Rams — Sunday, Oct. 18, 4:05 p.m.
• Los Angeles Chargers at Kansas City Chiefs — Sunday, Oct. 18, 4:25 p.m.
• Buffalo Bills at Las Vegas Raiders — Sunday, Oct. 18, 4:25 p.m.
• Dallas Cowboys at Green Bay Packers — Sunday, Oct. 18, 8:20 p.m.
• Washington Commanders at San Francisco 49ers — Monday, Oct. 19, 8:15 p.m.

The Week 6 NFL schedule is lighter than the opening weeks of the season, with 14 games on the slate. Sunday begins with a 9:30 a.m. ET matchup before seven games in the 1 p.m. window, followed by three later games and Cowboys-Packers on Sunday night. Seahawks-Broncos and Commanders-49ers provide the standalone Thursday and Monday games.

NFL Week 6 Odds

The early NFL Week 6 odds establish several clear favorites, but there are also a number of games with spreads around a field goal or less. The lines below are based on the supplied odds board and were reviewed Aug. 18, 2026. Because sportsbooks can move their numbers independently, these should be treated as an early betting-market snapshot rather than guaranteed closing lines.

Seattle is around a 1.5-point favorite against Denver, while Texans-Jaguars is priced close to a toss-up. Chicago is laying roughly three points against Atlanta, and Indianapolis is favored by approximately 3.5 points over Tennessee.

Some of the largest Week 6 NFL odds are attached to the Rams and Patriots. Los Angeles is roughly a 13.5-point favorite against Arizona, making it the largest favorite on the supplied board. New England is around -9.5 against the Jets, while Baltimore and Philadelphia are each favored by approximately 6.5 points.

Several games sit in a much tighter range. Tampa Bay is around -1.5 against Pittsburgh, Kansas City is favored by roughly 2.5 points against the Chargers, and Seattle is laying approximately 1.5 points at Denver. The Texans-Jaguars moneyline is nearly even.

Totals vary considerably. Cowboys-Packers carries one of the highest early totals at roughly 51.5 points, while Texans-Jaguars is among the lowest at approximately 42.5. Commanders-49ers also carries a relatively high total around 50.5.

With weeks remaining before kickoff, NFL odds for Week 6 can change because of injuries, roster developments, early-season performance, and betting action. Check current numbers in the Hall of Fame Bets sports betting app before placing a wager.

NFL Week 6 Predictions

Early NFL Week 6 predictions should be treated differently from the schedule and betting lines: these are analytical leans, not factual outcomes or guarantees.

Seahawks at Broncos: Seattle gets the early lean. The Seahawks are favored by roughly 1.5 points on the road, making this one of the closest matchups on the Week 6 board.

Texans vs. Jaguars: Houston gets a slight nod. The moneyline is essentially even and the spread offers little separation, so this is one of the most difficult Week 6 games to call from the early market.

Bears at Falcons: Chicago gets the prediction. The Bears are favored by around three points on the road, giving them a modest early advantage.

Ravens at Browns: Baltimore gets the early pick. The Ravens are favored by approximately 6.5 points on the road, making them one of the stronger favorites in Sunday's early window.

Titans at Colts: Indianapolis gets the prediction. The Colts are favored by roughly 3.5 points at home, although the spread leaves Tennessee within reasonable upset range.

Jets at Patriots: New England gets the pick. The Patriots are favored by approximately 9.5 points at home, giving them one of the largest early spreads of Week 6.

Saints at Giants: New York gets the early lean. The Giants are favored by roughly 2.5 points at home in another matchup the market expects to remain competitive.

Panthers at Eagles: Philadelphia gets the prediction. The Eagles are favored by approximately 6.5 points at home, putting them among Week 6's stronger favorites.

Steelers at Buccaneers: Tampa Bay gets a narrow lean. The Buccaneers are favored by roughly 1.5 points at home, suggesting little separation between these teams in the early market.

Cardinals at Rams: Los Angeles gets the prediction. The Rams are favored by approximately 13.5 points, making them the largest favorite on the supplied Week 6 odds board.

Chargers at Chiefs: Kansas City gets the early pick. The Chiefs are favored by roughly 2.5 points at home, but the narrow spread indicates the market expects a competitive divisional matchup.

Bills at Raiders: Buffalo gets the prediction. The Bills are favored by approximately 6.5 points on the road, giving them a substantial early advantage over Las Vegas.

Cowboys at Packers: Green Bay gets the Sunday night lean. The Packers are favored by around three points at home, while the 51.5-point total makes this one of the highest-scoring projections of Week 6.

Commanders at 49ers: San Francisco gets the Monday night prediction. The 49ers are favored by approximately 5.5 points at home, while the total around 50.5 suggests the early market sees significant scoring potential.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 6?

Based on the supplied early NFL Week 6 odds, the Rams are the biggest favorite, laying roughly 13.5 points against the Cardinals. New England is around a 9.5-point favorite over the Jets, while Baltimore, Philadelphia, and Buffalo are each favored by approximately 6.5 points.

San Francisco is also favored by more than a field goal against Washington. At the opposite end of the spectrum, Texans-Jaguars is essentially a toss-up, while Seahawks-Broncos and Steelers-Buccaneers have spreads around 1.5 points.

Being favored does not mean a team is predicted to win with certainty. Point spreads reflect the betting market and can change substantially between the opening numbers and kickoff.

What Are the Odds for NFL Week 6?

NFL Week 6 odds include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for the combined points scored by both teams.

For Week 6 of the 2026 season, the supplied odds show a wide range of expectations. The Rams are favored by roughly 13.5 points against Arizona, while Houston-Jacksonville is priced close to a pick'em. Seattle-Denver and Pittsburgh-Tampa Bay are also separated by less than a field goal.

Totals vary across the Week 6 NFL schedule. Cowboys-Packers is among the highest at roughly 51.5 points, with Commanders-49ers around 50.5. Texans-Jaguars sits toward the lower end of the board at approximately 42.5.

Our sports betting app's compare the latest market before making a decision because these early numbers can move as Week 6 approaches.

Who Is Predicted to Win Week 6 in the NFL?

Our early Week 6 NFL predictions lean toward Seattle, Houston, Chicago, Baltimore, Indianapolis, New England, the Giants, Philadelphia, Tampa Bay, the Rams, Kansas City, Buffalo, Green Bay, and San Francisco.

Those selections are preliminary. Results from the opening weeks, injuries, roster changes, depth-chart decisions, and updated betting markets can alter the analysis before kickoff.

The Week 6 schedule offers a mix of close games and substantial favorites, with Seahawks-Broncos opening the week and Commanders-49ers closing it on Monday night. As kickoff approaches, updated NFL Week 6 odds and matchup-specific analysis will provide a clearer picture of where the strongest predictions and betting opportunities may be.