Saints vs Giants NFL Picks and Predictions
Our Saints vs Giants NFL picks and predictions cover the (1-4) New Orleans Saints at the (3-1-1) New York Giants on Sunday, October 18th at 1:00 PM ET. Check out our full Week 6 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Saints vs Giants NFL Player Props and DFS Picks article.
Table of Contents
Odds
New Orleans is a road favorite at -1.5 (+111) on the spread with a -108 moneyline, while New York sits at +1.5 (-117) on the spread and +104 on the moneyline. The total is set at 44.5, with the over priced at -110 and the under at +111 — an unusual spot with a 1-4 team favored on the road.
Matchup Breakdown
New Orleans's offense grades out well in the scoring categories against New York's defense, ranking 8th in Anytime TDs, 11th in Pass TDs, and 11th in Rush TDs, but ranks 29th in Rush Yards and 20th in Rush+Rec Yards. New York's defense ranks 7th against Pass Yards, and Shough carries a D matchup grade with a projection of 259.8 passing yards and 1.8 touchdowns.
New York's offense faces a much weaker defense, as New Orleans ranks 30th against Anytime TDs, 30th against Rush Yards, 25th against Rush+Rec Yards, and 32nd against Rush TDs. New York's own offense ranks 32nd in Rush TDs, and Winston carries a C- matchup grade with a projection of 201.3 passing yards and 1.5 touchdowns.
Injury Report
T. Etienne (NO) – Strain, Out (10/1).
D. Singletary (NYG) – Coach's Decision, Out (10/4).
B. Berrios (NYG) – Surgery, Out (10/7).
J. Dart (NYG) – Surgery, Out (9/30).
Betting Trends
New Orleans has covered the -1.5 spread in just 20% of its games and hit the moneyline in 20%, while New York has covered the +1.5 spread in 80% of its games and hit the moneyline in 70%. The trend data leans heavily toward the Giants, who also hold the much better record.
Our Pick
Pick: Giants +1.5. New Orleans is 1-4 and has covered in just 20% of its games, yet it is laying points on the road against a Giants team that has covered in 80% of its games. New Orleans's defense ranks 30th against Anytime TDs and 32nd against Rush TDs, which gives New York a real path to scoring. We like the Giants to take the points, with a shot at the outright win.
How We Made Our Saints vs Giants NFL Picks and Predictions
Our Saints vs Giants NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 6 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.