NFL Week 12 Schedule, Odds, and Predictions (2026)

The 2026 NFL Week 12 schedule begins with the Green Bay Packers visiting the Los Angeles Rams on Wednesday, Nov. 25, before a Thanksgiving tripleheader featuring Bears-Lions, Eagles-Cowboys, and Chiefs-Bills. The week continues through Sunday and concludes with the Carolina Panthers visiting the Tampa Bay Buccaneers on Monday night.

Sunday's slate includes Saints-Bengals, Ravens-Texans, Jets-Dolphins, Commanders-Cardinals, Seahawks-49ers, and Patriots-Chargers. Early NFL Week 12 odds are available for the first five games on the supplied board, while the remainder of the week's betting markets have not yet been posted.

Below is the complete NFL schedule for Week 12, followed by an early look at NFL Week 12 odds and predictions. Betting lines are snapshots and can move significantly before kickoff.

NFL Week 12 Schedule

Here is the Week 12 NFL schedule for the 2026 season. All kickoff times below are Eastern Time.

• Green Bay Packers at Los Angeles Rams — Wednesday, Nov. 25, 8:00 p.m.
• Chicago Bears at Detroit Lions — Thursday, Nov. 26, 1:00 p.m.
• Philadelphia Eagles at Dallas Cowboys — Thursday, Nov. 26, 4:30 p.m.
• Kansas City Chiefs at Buffalo Bills — Thursday, Nov. 26, 8:20 p.m.
• Denver Broncos at Pittsburgh Steelers — Friday, Nov. 27, 3:00 p.m.
• New Orleans Saints at Cincinnati Bengals — Sunday, Nov. 29, 1:00 p.m.
• Las Vegas Raiders at Cleveland Browns — Sunday, Nov. 29, 1:00 p.m.
• Baltimore Ravens at Houston Texans — Sunday, Nov. 29, 1:00 p.m.
• New York Giants at Indianapolis Colts — Sunday, Nov. 29, 1:00 p.m.
• New York Jets at Miami Dolphins — Sunday, Nov. 29, 1:00 p.m.
• Atlanta Falcons at Minnesota Vikings — Sunday, Nov. 29, 1:00 p.m.
• Tennessee Titans at Jacksonville Jaguars — Sunday, Nov. 29, 4:05 p.m.
• Washington Commanders at Arizona Cardinals — Sunday, Nov. 29, 4:25 p.m.
• Seattle Seahawks at San Francisco 49ers — Sunday, Nov. 29, 4:25 p.m.
• New England Patriots at Los Angeles Chargers — Sunday, Nov. 29, 8:20 p.m.
• Carolina Panthers at Tampa Bay Buccaneers — Monday, Nov. 30, 8:15 p.m.

The Week 12 NFL schedule features a full 16-game slate and an unusual five-day run of games. Green Bay-Los Angeles starts the week Wednesday before three Thanksgiving games Thursday and Broncos-Steelers on Friday. Sunday carries 10 games, with Panthers-Buccaneers finishing Week 12 on Monday night.

NFL Week 12 Odds

The early NFL Week 12 odds are only partially available. The lines below are based on the supplied odds board and were reviewed Aug. 19, 2026. Complete early moneylines, spreads, and totals are shown for the Wednesday, Thursday, and Friday games, while Sunday's and Monday's matchups do not yet have odds posted.

The Rams are approximately 5.5-point favorites against Green Bay and around -230 on the moneyline. The Packers are approximately +198, while the total is around 48.5 points.

Detroit is roughly a 2.5-point favorite over Chicago. The Lions are around -132 on the moneyline compared with +115 for the Bears, and the total is approximately 53.5 points—the highest among the Week 12 games currently carrying odds.

Dallas is approximately a 1.5-point favorite against Philadelphia, making that Thanksgiving matchup one of the closest early games. The Cowboys are around -120 on the moneyline, while the Eagles are approximately +105. The total is around 49.5.

Buffalo is favored by roughly 2.5 points over Kansas City in the Thanksgiving night game. The Bills are approximately -146 on the moneyline, with the Chiefs around +130, and the total is approximately 50.5 points.

Friday's Denver-Pittsburgh matchup is another tight market. Denver is approximately a 1.5-point road favorite and around -115 on the moneyline, while Pittsburgh is approximately +114. The total is around 39.5, the lowest of the games with early Week 12 odds available.

No odds are displayed on the supplied board for the remaining Sunday and Monday games, so those spreads, moneylines, and totals should not be estimated.

NFL odds for Week 12 can change substantially based on injuries, performance during the season, roster developments, and betting activity. Check current numbers in the Hall of Fame Bets sports betting app before making a wager.

NFL Week 12 Predictions

Early NFL Week 12 predictions are analytical leans rather than guarantees. For games without posted odds, the selections are especially preliminary and should be reassessed as Week 12 approaches.

Packers at Rams: Los Angeles gets the prediction. The Rams are favored by approximately 5.5 points at home, the largest spread among the Week 12 games currently carrying odds.

Bears at Lions: Detroit gets the Thanksgiving prediction. The Lions are favored by roughly 2.5 points, while the 53.5-point total is the highest currently available on the Week 12 board.

Eagles at Cowboys: Dallas gets a narrow lean. The Cowboys are favored by approximately 1.5 points at home, suggesting little separation between the NFC rivals.

Chiefs at Bills: Buffalo gets the Thanksgiving night pick. The Bills are favored by roughly 2.5 points at home, but the relatively small spread points toward a competitive matchup.

Broncos at Steelers: Denver gets the Friday prediction. The Broncos are favored by approximately 1.5 points on the road, while the total around 39.5 suggests a lower-scoring outlook than the other games with posted odds.

Saints at Bengals: Cincinnati gets the early lean at home. No Week 12 odds were available on the supplied board, so the prediction is not based on a current betting market.

Raiders at Browns: Cleveland gets the prediction. No early spread or moneyline was supplied, making this a preliminary analytical selection.

Ravens at Texans: Baltimore gets a slight lean. Without a posted Week 12 line, this matchup should be reassessed once the market provides more context.

Giants at Colts: Indianapolis gets the early prediction at home. No odds were available on the supplied board.

Jets at Dolphins: Miami gets the pick at home. With no Week 12 betting market currently listed, the selection remains preliminary.

Falcons at Vikings: Minnesota gets the early lean. No spread or moneyline was supplied for the matchup, so the eventual market will provide additional context.

Titans at Jaguars: Jacksonville gets the prediction at home. The Week 12 odds have not yet been posted on the supplied board for this divisional matchup.

Commanders at Cardinals: Arizona gets a narrow home lean. No early odds are available, making this one to revisit closer to kickoff.

Seahawks at 49ers: San Francisco gets the prediction at home. No Week 12 betting line was supplied, so this selection is analytical rather than market-based.

Patriots at Chargers: Los Angeles gets the Sunday night lean. With no early odds posted, the prediction remains subject to revision as the season develops.

Panthers at Buccaneers: Tampa Bay gets the Monday night prediction. No Week 12 spread or moneyline was available on the supplied board.

For deeper matchup analysis throughout the season, see our NFL picks.

Who Is Favored to Win in NFL Week 12?

Based on the supplied early NFL Week 12 odds, the Rams are the biggest favorite among games with a posted market, laying approximately 5.5 points against Green Bay.

Detroit and Buffalo are each favored by roughly 2.5 points, while Dallas and Denver are around 1.5-point favorites. Those numbers cover only five games, however. Odds have not yet been posted on the supplied board for the remaining Week 12 matchups, so the Rams cannot yet be identified as the biggest favorite across the complete schedule.

Being favored does not guarantee a victory. Point spreads represent the betting market at a particular moment and can move considerably before kickoff.

What Are the Odds for NFL Week 12?

NFL Week 12 odds generally include three primary markets: the moneyline, point spread, and game total. The spread measures the expected margin between the teams, the moneyline prices each team's chances of winning outright, and the total sets a number for their combined points.

Among the games currently carrying odds, Los Angeles is around -5.5 against Green Bay, Detroit is approximately -2.5 against Chicago, Dallas is -1.5 against Philadelphia, Buffalo is -2.5 against Kansas City, and Denver is -1.5 against Pittsburgh.

The available totals range from approximately 39.5 for Broncos-Steelers to 53.5 for Bears-Lions. The remaining Week 12 games do not yet have odds displayed on the supplied board and should be updated once those markets become available.

Who Is Predicted to Win Week 12 in the NFL?

Our early Week 12 NFL predictions lean toward the Rams, Detroit, Dallas, Buffalo, Denver, Cincinnati, Cleveland, Baltimore, Indianapolis, Miami, Minnesota, Jacksonville, Arizona, San Francisco, the Chargers, and Tampa Bay.

Those selections are preliminary, particularly for the 11 games without posted odds on the supplied board. Injuries, results from the first 11 weeks, roster changes, depth-chart decisions, and updated betting markets can materially change the outlook before kickoff.

The Week 12 NFL schedule is one of the season's most spread-out slates, beginning Wednesday and featuring three Thanksgiving games before continuing through Monday night. As the week approaches, updated NFL Week 12 odds and matchup-specific analysis will provide a clearer picture of the strongest predictions and betting opportunities.