Raiders vs 49ers NFL Picks and Predictions
Our Raiders vs 49ers NFL picks and predictions cover the (4-4) Las Vegas Raiders at the (6-1) San Francisco 49ers on Sunday, November 8th at 4:25 PM ET. Check out our full Week 9 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Raiders vs 49ers NFL Player Props and DFS Picks article.
Table of Contents
Odds
San Francisco is favored at -10 (-101) on the spread with a -443 moneyline, while Las Vegas sits at +10 (-106) on the spread and +430 on the moneyline. The total is set at 51.5, with the over priced at -108 and the under at +100.
Matchup Breakdown
Las Vegas' offense is a passing attack against San Francisco's defense, ranking 3rd in both Pass Yards at 265.1 and Pass TDs at 2.4, 10th in Anytime TDs, and 13th in Rush+Rec Yards, though it ranks 31st in both Rush Yards and Rush TDs. San Francisco's defense ranks 2nd against Rush TDs, 4th against Rush+Rec Yards, 5th against both Anytime TDs and Rush Yards, 11th against Pass Yards, and 19th against Pass TDs, and K. Cousins carries a D+ matchup grade with a projection of 265.5 passing yards, 2.4 touchdowns, and 0.6 interceptions.
San Francisco's offense is one of the strongest in the league against Las Vegas' defense, ranking 2nd in Anytime TDs at 3.7, 3rd in Rush TDs, 4th in Pass TDs, 6th in Rush+Rec Yards, 8th in Rush Yards, and 12th in Pass Yards. Las Vegas' defense is a clear weakness, ranking 31st against both Anytime TDs and Rush Yards, 30th against both Rush+Rec Yards and Pass TDs, 25th against both Pass Yards and Rush TDs, and B. Purdy carries a B+ matchup grade with a projection of 249.7 passing yards, 2.1 touchdowns, and 0.6 interceptions.
Injury Report
C. McCaffrey (SF) – Hamstring, Questionable (10/26).
M. Evans (SF) – Tendinitis, Questionable (10/26).
D. Samuel (SF) – Hamstring, Questionable (10/26).
N. Bosa (SF) – Strain, Questionable (10/26).
M. Benson (LV) – Coach's Decision, Out (11/1).
Betting Trends
Las Vegas has covered the +9.5 spread in 75% of its games and hit the moneyline in 50%, while San Francisco has covered the -9.5 spread in 43% of its games and hit the moneyline in 86%. San Francisco holds the better record at 6-1 versus Las Vegas's 4-4.
Our Pick
Pick: Over 51.5 (-102). San Francisco's offense ranks 2nd in Anytime TDs and 4th in Pass TDs against a Las Vegas defense that ranks 31st against Anytime TDs and 30th against Pass TDs, while Las Vegas' offense ranks 3rd in both Pass Yards and Pass TDs. With both teams carrying strong passing numbers and Las Vegas' defense grading poorly across the board, we like this game to clear one of the highest totals of the week, even with several San Francisco skill players listed as questionable.
How We Made Our Raiders vs 49ers NFL Picks and Predictions
Our Raiders vs 49ers NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 9 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.