Rams vs Broncos NFL Picks and Predictions

Our Rams vs Broncos NFL picks and predictions break down every angle of this Week 3 matchup, from the point spread and moneyline to the total, injury report, and betting trends.

The Los Angeles Rams (1-1) travel to Denver to take on the Broncos (1-1) in a Week 3 Sunday night matchup on September 27th at 8:20 PM ET. Check out our full Week 3 NFL Schedule for odds and predictions on every game this week.

All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Rams vs Broncos NFL Player Props and DFS Picks article.

Odds

Spread: Rams -2.5 (-108) | Broncos +2.5 (-102)

Moneyline: Rams -133 | Broncos +122

Total: 45.5 | Over -100 | Under -108

Matchup Breakdown

This one is a mixed bag on paper. The Rams offense grades out ahead of the Broncos defense in the run game (10th in Rush Yards and 13th in Rush TDs against a Broncos defense ranking 22nd in both), but Denver's defense grades out better against the pass (8th in Pass Yards allowed, 15th in Anytime TDs allowed). On the other side, the Broncos offense ranks near the bottom of the league across the board (21st, 16th, 16th, 20th, 11th, and 23rd), and while the Rams defense leaks some rushing yardage (29th), it grades out elite at limiting rushing touchdowns (1st) and anytime touchdowns (7th).

At quarterback, Matthew Stafford is projected for a strong 296.8 passing yards and 2.2 touchdowns, but still carries a D- matchup grade against Denver. Bo Nix grades out better at a C against Los Angeles, projected for 246.1 passing yards, 1.2 touchdowns, and 0.6 interceptions.

Injury Report

M. Caldwell (LA) – Undisclosed, Out (8/29)

N. Landman (LA) – Shoulder, Questionable (9/17)

O. Speights (LA) – Bruise, Questionable (9/17)

R. Harvey (DEN) – Hamstring, Questionable (9/17)

M. Mims (DEN) – Foot, Questionable (9/17)

C. Lohner (DEN) – Surgery, Out (8/31)

Betting Trends

Moneyline: 67% of bettors are backing the Rams moneyline (-127) in Los Angeles's games, while 75% are on the Broncos (+117) in Denver's games.

Spread: 62% are on Rams -2.5 in Los Angeles's games, compared to 80% on Broncos +2.5 in Denver's games.

Total: 62% of Rams games and 35% of Broncos games are trending Over this season, while 38% of Rams games and 65% of Broncos games are trending Under.

Our Pick

Denver's offense grades out near the bottom of the league across the board, and while the Rams defense has some soft spots against the run, it grades out elite at preventing touchdowns — which is ultimately what decides games. We'll side with the more complete team here.

Pick: Rams -2.5

How We Made Our Rams vs Broncos NFL Picks and Predictions

Our Rams vs Broncos NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 3 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.

We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.