Raiders vs Saints NFL Picks and Predictions

Our Raiders vs Saints NFL picks and predictions break down every angle of this Week 3 matchup, from the point spread and moneyline to the total, injury report, and betting trends.

The Las Vegas Raiders (2-0) travel to New Orleans to take on the Saints (1-1) in a Week 3 matchup on Sunday, September 27th at 4:25 PM ET. Check out our full Week 3 NFL Schedule for odds and predictions on every game this week.

All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Raiders vs Saints NFL Player Props and DFS Picks article.

Odds

Spread: Raiders +3 (+100) | Saints -3 (-115)

Moneyline: Raiders +163 | Saints -168

Total: 44 | Over -105 | Under -108

Matchup Breakdown

The Raiders offense holds a clear edge against a shaky Saints defense, ranking 10th in Rush+Rec Yards, 17th in Anytime TDs, 18th in Pass Yards, 9th in Rush Yards, 15th in Pass TDs, and 17th in Rush TDs against a Saints defense that ranks 27th, 23rd, 21st, 25th, 18th, and 27th in those categories. The other side of the ball is more competitive: the Saints offense ranks 5th, 9th, 5th, 18th, 18th, and 7th against a Raiders defense that grades out at 12th, 9th, 9th, 17th, 12th, and 10th.

At quarterback, Tyler Shough is projected for 266.6 passing yards, 1.3 touchdowns, and 0.7 interceptions, but carries just a D+ matchup grade against Las Vegas. Kirk Cousins grades out better at a B- against New Orleans, projected for 186.6 passing yards, 1.4 touchdowns, and 0.8 interceptions.

Injury Report

B. Bowers (LV) – Surgery, Questionable (9/17)

D. Thornton (LV) – Undisclosed, Out (8/31)

C. Olave (NO) – Hamstring, Questionable (9/17)

J. Johnson (NO) – Illness, Questionable (9/17)

M. Matavao (NO) – Knee, Out (8/25)

A. Estime (NO) – Thigh, Out (9/12)

Betting Trends

Moneyline: Just 22% of bettors have backed the Raiders moneyline (+146) in Las Vegas's games this season, while 33% have gone with the Saints (-159) in New Orleans's games.

Spread: 39% are on Raiders +3 in Las Vegas's games, compared to 28% on Saints -3 in New Orleans's games.

Total: 33% of Raiders games and 28% of Saints games are trending Over this season, while 67% of Raiders games and 72% of Saints games are trending Under.

Our Pick

Las Vegas's offense grades out with a real advantage against a Saints defense that ranks near the bottom of the league across the board, and Kirk Cousins carries a notably better matchup grade than Tyler Shough this week. We like the Raiders to keep this one close.

Pick: Raiders +3

How We Made Our Raiders vs Saints NFL Picks and Predictions

Our Raiders vs Saints NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 3 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.

We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.