Eagles vs Bears NFL Picks and Predictions

Our Eagles vs Bears NFL picks and predictions break down every angle of this Week 3 matchup, from the point spread and moneyline to the total, injury report, and betting trends.

The Philadelphia Eagles (2-0) travel to Chicago to take on the Bears (1-1) in the Week 3 Monday Night Football matchup on September 28th at 8:15 PM ET. Check out our full Week 3 NFL Schedule for odds and predictions on every game this week.

All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Eagles vs Bears NFL Player Props and DFS Picks article.

Odds

Spread: Eagles -3 (-112) | Bears +3 (+106)

Moneyline: Eagles -170 | Bears +162

Total: 43.5 | Over -103 | Under -109

Matchup Breakdown

This is a lopsided matchup on one side of the ball. The Bears offense grades out elite against the Eagles defense, ranking 3rd in Rush+Rec Yards, 2nd in Anytime TDs, 1st in Pass Yards, 8th in Rush Yards, 6th in Pass TDs, and 2nd in Rush TDs — while Philadelphia's defense ranks 31st, 27th, 25th, 31st, 27th, and 28th in those same categories. The other side is more even: the Eagles offense ranks 28th, 15th, 27th, 25th, 7th, and 28th against a Bears defense that grades out at 25th, 22nd, 31st, 10th, 24th, and 18th.

Injury Report

D. Swift (CHI) – Ankle, Questionable (9/17)

K. Monangai (CHI) – Hamstring, Questionable (9/17)

B. Brown (CHI) – Undisclosed, Out (8/31)

N. Kalinic (CHI) – Knee, Out (8/18)

H. Large (CHI) – Undisclosed, Out (9/1)

E. Stowers (PHI) – Hamstring, Out (9/12)

Betting Trends

Moneyline: 63% of bettors are backing the Eagles moneyline (+104) in Philadelphia's games, while 65% are on the Bears (-112) in Chicago's games.

Spread: 63% are on Eagles +1.5 in Philadelphia's games, compared to 55% on Bears -1.5 in Chicago's games.

Total: 26% of Eagles games and 50% of Bears games are trending Over this season, while 74% of Eagles games and 50% of Bears games are trending Under.

Our Pick

Chicago's offense grades out as one of the best matchups on the board against a Philadelphia defense that ranks near the bottom of the league across the board, and that gap is too significant to ignore even with the Eagles holding the better quarterback matchup grade.

Pick: Bears -1.5

How We Made Our Eagles vs Bears NFL Picks and Predictions

Our Eagles vs Bears NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 3 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.

We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.