Rams vs Raiders NFL Picks and Predictions
Our Rams vs Raiders NFL picks and predictions cover the (2-4) Los Angeles Rams at the (3-3) Las Vegas Raiders on Sunday, October 25th at 4:25 PM ET. Check out our full Week 7 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Rams vs Raiders NFL Player Props and DFS Picks article.
Table of Contents
Odds
Los Angeles is favored at -4.5 (-105) on the spread with a -199 moneyline, while Las Vegas sits at +4.5 (-110) on the spread and +194 on the moneyline. The total is set at 47.5, with the over priced at -104 and the under at +100.
Matchup Breakdown
The Rams' offense grades out as one of the best in the league against Las Vegas' defense, ranking 2nd in Pass Yards, 3rd in Rush+Rec Yards, 12th in Anytime TDs, and 13th in Pass TDs. Las Vegas' defense is a clear weakness, ranking 28th against both Rush+Rec Yards and Rush Yards, 27th against both Anytime TDs and Pass TDs, and 24th against Pass Yards, and Stafford carries a B matchup grade with a projection of 299 passing yards and 1.8 touchdowns.
Las Vegas' offense grades out well through the air against the Rams' defense, ranking 4th in Pass TDs, 7th in Pass Yards, and 11th in Anytime TDs, though it ranks 30th in Rush Yards and 28th in Rush TDs. The Rams' defense is strong, ranking 2nd against Pass Yards, 3rd against Rush+Rec Yards, and 11th against Rush TDs, and Cousins carries an F matchup grade with a projection of 263.7 passing yards and 2.3 touchdowns.
Injury Report
T. Ferguson (LA) – Sprain, Out (10/7).
T. Atwell (LA) – Coach's Decision, Out (10/18).
B. Grupe (LA) – Knee, Questionable (10/18).
J. Bech (LV) – Fracture, Out (9/29).
Betting Trends
Los Angeles has covered the -5.5 spread in just 17% of its games and hit the moneyline in 33%, while Las Vegas has covered the +5.5 spread in 83% of its games and hit the moneyline in 50%. The trend data runs against the Rams, even though the matchup grades favor them.
Our Pick
Pick: Rams -5.5. This is a pick where the matchup grades and the trend data disagree, and we side with the matchups. Los Angeles ranks 2nd in Pass Yards and 3rd in Rush+Rec Yards against a Las Vegas defense that ranks 28th against Rush+Rec Yards and 27th against both Anytime TDs and Pass TDs, and Stafford projects for 299 passing yards and 1.8 touchdowns. Las Vegas has covered in 83% of its games, but Cousins carries an F matchup grade against a Rams defense ranked 2nd against Pass Yards. We like the Rams to cover, with the caveat that the trend favors the Raiders.
How We Made Our Rams vs Raiders NFL Picks and Predictions
Our Rams vs Raiders NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 7 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.