Packers vs Lions NFL Picks and Predictions
Our Packers vs Lions NFL picks and predictions cover the (4-2) Green Bay Packers at the (3-2) Detroit Lions on Sunday, October 25th at 4:25 PM ET. Check out our full Week 7 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Packers vs Lions NFL Player Props and DFS Picks article.
Table of Contents
Odds
Detroit is favored at -3 (-105) on the spread with a -156 moneyline, while Green Bay sits at +3 (+100) on the spread and +150 on the moneyline. The total is set at 53.5, with the over priced at -102 and the under at +100 — the highest total on the Week 7 slate.
Matchup Breakdown
Green Bay's offense grades out well through the air against Detroit's defense, ranking 5th in Pass Yards and 9th in Pass TDs, along with 18th in Rush+Rec Yards and 21st in Anytime TDs, though it ranks 32nd in Rush Yards. Detroit's defense is a major weakness, ranking 32nd against Rush+Rec Yards, Anytime TDs, and Pass Yards and 31st against Pass TDs, and J. Love carries an A+ matchup grade with a projection of 280.7 passing yards and 1.8 touchdowns.
Detroit's offense grades out as one of the best in the league against Green Bay's defense, ranking 2nd in both Anytime TDs and Pass TDs, 3rd in both Pass Yards and Rush TDs, and 4th in Rush+Rec Yards. Green Bay's defense is strong against the pass, ranking 6th against Pass Yards and 10th against Rush+Rec Yards, but it ranks 30th against Rush TDs, and Goff carries a D- matchup grade with a projection of 297 passing yards and 2.4 touchdowns.
Injury Report
C. Brooks (GB) – Ankle, Out (10/10).
S. Moore (GB) – Ankle, Out (10/17).
J. Reed (GB) – Surgery, Out (9/30).
T. Kennedy (DET) – Surgery, Out (10/16).
Betting Trends
Green Bay has covered the +3.5 spread in 67% of its games and hit the moneyline in 67%, while Detroit has covered the -3.5 spread in 40% of its games and hit the moneyline in 60%. Green Bay holds the slightly better record at 4-2 versus Detroit's 3-2.
Our Pick
Pick: Over 52.5. This is the highest total on the Week 7 slate, and the matchup grades support it. Detroit's defense ranks 32nd against Rush+Rec Yards, Anytime TDs, and Pass Yards and 31st against Pass TDs, while Detroit's own offense ranks 2nd in both Anytime TDs and Pass TDs. The two quarterbacks project for a combined 577.7 passing yards, with J. Love at 1.8 touchdowns and Goff at 2.4. We like this game to clear the number.
How We Made Our Packers vs Lions NFL Picks and Predictions
Our Packers vs Lions NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 7 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.