Cardinals vs Cowboys NFL Picks and Predictions
Our Cardinals vs Cowboys NFL picks and predictions cover the (2-5) Arizona Cardinals at the (3-4) Dallas Cowboys on Sunday, November 1st at 1:00 PM ET. Check out our full Week 8 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Cardinals vs Cowboys NFL Player Props and DFS Picks article.
Table of Contents
Odds
Dallas is favored at -6.5 (+100) on the spread with a -251 moneyline, while Arizona sits at +6.5 (-110) on the spread and +245 on the moneyline. The total is set at 53.5, with the over priced at -106 and the under at +101 — tied for the highest total on the Week 8 slate.
Matchup Breakdown
Arizona's offense grades out in the lower half of the league against Dallas' defense, ranking 19th in Pass Yards, 22nd in both Rush+Rec Yards and Pass TDs, 23rd in Rush Yards, and 27th in Anytime TDs. Dallas' defense is a clear weakness, ranking 31st against Rush Yards, 30th against Rush+Rec Yards, and 25th against Pass TDs, and J. Brissett carries a C+ matchup grade with a projection of 228.6 passing yards and 1.4 touchdowns.
Dallas' offense grades out well against Arizona's defense, ranking 6th in Pass Yards, 6th in Rush TDs, 9th in Anytime TDs, and 15th in Rush+Rec Yards, though it ranks 30th in Rush Yards. Arizona's defense ranks 32nd against Anytime TDs, 29th against Pass TDs, and 24th against both Rush+Rec Yards and Rush Yards, and Prescott carries a B- matchup grade with a projection of 273.2 passing yards and 1.7 touchdowns.
Injury Report
K. Turpin (DAL) – Ribs, Out (10/24).
J. Love (ARI) – Ankle, Out (10/23).
H. Long (ARI) – Knee, Out (10/6).
Betting Trends
Arizona has covered the +6.5 spread in 43% of its games and hit the moneyline in 29%, while Dallas has covered the -6.5 spread in just 17% of its games and hit the moneyline in 33%. Neither team has been reliable, and both sit near the bottom of the standings at 2-5 for Arizona and 2-4 for Dallas.
Our Pick
Pick: Over 53.5. Both defenses are among the weakest in the league: Dallas ranks 31st against Rush Yards and 30th against Rush+Rec Yards, while Arizona ranks 32nd against Anytime TDs and 29th against Pass TDs. Prescott projects for 273.2 passing yards and 1.7 touchdowns, and Brissett projects for 228.6 passing yards and 1.4 touchdowns. With J. Love out for Arizona and K. Turpin out for Dallas, the injury report is not enough to offset the defensive matchups. We like this game to clear a high total.
How We Made Our Cardinals vs Cowboys NFL Picks and Predictions
Our Cardinals vs Cowboys NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 8 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.