Broncos vs Cardinals NFL Picks and Predictions
Our Broncos vs Cardinals NFL picks and predictions cover the (4-2) Denver Broncos at the (2-4) Arizona Cardinals on Sunday, October 25th at 4:05 PM ET. Check out our full Week 7 NFL Schedule for odds and predictions on every game this week.
All of the odds, matchup grades, injury data, and betting trends referenced below come from HOF's sports betting research app, which tracks live lines and team/player data to help bettors make more informed decisions. For our top touchdown scorer prop picks and DFS plays in this game, check out our Broncos vs Cardinals NFL Player Props and DFS Picks article.
Table of Contents
Odds
Denver is favored at -4.5 (-102) on the spread with a -208 moneyline, while Arizona sits at +4.5 (+100) on the spread and +203 on the moneyline. The total is set at 43.5, with the over priced at +102 and the under at -105.
Matchup Breakdown
Denver's offense grades out near the bottom of the league against Arizona's defense, ranking 31st in Rush+Rec Yards, 28th in Pass Yards, 26th in Rush Yards, 25th in Pass TDs, and 24th in Anytime TDs. Arizona's defense is a weakness, ranking 31st against Anytime TDs, 30th against Pass TDs, 24th against Rush+Rec Yards, and 22nd against Pass Yards, and Nix carries a B matchup grade with a projection of 174.8 passing yards and 1 touchdown.
Arizona's offense also grades out in the lower half of the league against Denver's defense, ranking 17th in Pass TDs, 20th in Pass Yards, 22nd in Rush Yards, 23rd in Rush+Rec Yards, and 25th in Anytime TDs. Denver's defense ranks 8th against Pass TDs, 10th against Anytime TDs, and 11th against Pass Yards, but it ranks 31st against Rush Yards, and Brissett carries a C matchup grade with a projection of 221.3 passing yards and 1.5 touchdowns.
Injury Report
J. Love (ARI) – Ankle, Out (10/16).
H. Long (ARI) – Knee, Out (10/6).
P. Bryant (DEN) – Sprain, Out (10/9).
P. Surtain (DEN) – Sprain, Out (10/14).
T. Badie (DEN) – Thumb, Questionable (10/15).
Betting Trends
Denver has covered the -4.5 spread in 33% of its games and hit the moneyline in 67%, while Arizona has covered the +4.5 spread in 33% of its games and hit the moneyline in 33%. Denver holds the better record at 4-2 versus Arizona's 2-4, but neither team has been reliable against the number.
Our Pick
Pick: Cardinals +4.5. Denver's offense ranks 31st in Rush+Rec Yards and 28th in Pass Yards, and Nix projects for just 174.8 passing yards and 1 touchdown, while Brissett projects for 221.3 passing yards and 1.5 touchdowns against a Denver defense that ranks 31st against Rush Yards. Denver has covered in only 33% of its games and is without P. Surtain and P. Bryant. Arizona has a long injury list of its own, including J. Love, but we like the Cardinals to take the points.
How We Made Our Broncos vs Cardinals NFL Picks and Predictions
Our Broncos vs Cardinals NFL picks and predictions are built directly from HOF's sports betting research app rather than gut feel or outside commentary. For every Week 7 matchup, we start with HOF's live point spread, moneyline, and total, then layer in the team grades HOF assigns across offense and defense to see where a real statistical edge exists. From there, we cross-reference HOF's injury report to confirm which players are active, questionable, or out, since a single absence can shift a matchup grade significantly.
We also check HOF's betting trends data — how each team has performed against the spread and the total recently — to see whether the market is lining up with or against the statistical picture. Only after weighing the odds, the matchup grades, the injury report, and the betting trends together do we land on the spread, moneyline, or total pick we publish here. We don't publish a pick without a clear data-backed reason behind it, and we update our numbers as HOF's app updates its own lines and grades throughout the week.
Because lines and injury designations can move between now and kickoff, we recommend checking HOF's app for the latest numbers before placing any wager. A pick that looks strong at one number can lose its edge at another, so the price you can get matters just as much as the side you like.